Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1

Kimura, Taro; Kato, Eisuke; Machikawa, Tsukasa et al.

Biochemical and Biophysical Research Communications, 2014, 445(1), 6-9

Permalink : https://hdl.handle.net/2115/54788

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アクセス権
open access
URI
https://hdl.handle.net/2115/54788
タイトル
Hydroxylamine enhances glucose uptake in C2C12 skeletal muscle cells through the activation of insulin receptor substrate 1
著者
Kimura, Taro ; Kato, Eisuke ; Machikawa, Tsukasa ; Kimura, Shunsuke ; Katayama, Shinji ; Kawabata, Jun
著者名
Kimura, Taro
e-Rad_Researcher
40466446
著者名
Kato, Eisuke
著者名
Machikawa, Tsukasa
e-Rad_Researcher
40444525
著者名
Kimura, Shunsuke
著者名
Katayama, Shinji
e-Rad_Researcher
60142197
著者名
Kawabata, Jun
言語
英語
キーワード
Diabetes mellitus
Insulin
Glucose uptake
Hydroxylamine
PI3 K/Akt signaling
Skeletal muscle
発行日
2014-02
出版者
Elsevier
収録物名
Biochemical and Biophysical Research Communications
巻(号)
445(1)
ページ
6-9
抄録
Diabetes mellitus is a global disease, and the number of patients with it is increasing. Of various agents for treatment, those that directly act on muscle are currently attracting attention because muscle is one of the main tissues in the human body, and its metabolism is decreased in type II diabetes. In this study, we found that hydroxylamine (HA) enhances glucose uptake in C2C12 myotubes. Analysis of HA’s mechanism revealed the involvement of IRS1, PI3 K and Akt that is related to the insulin signaling pathway. Further investigation about the activation mechanism of insulin receptor or IRS1 by HA may provide a way to develop a novel anti-diabetic agent alternating to insulin.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
関連情報
PMID
24462868
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2014.01.039