Magnetoencephalography localizing spike sources of atypical benign partial epilepsy

Shiraishi, Hideaki; Haginoya, Kazuhiro; Nakagawa, Eiji et al.

Brain & development, 2014, 36(1), 21-27

Permalink : https://hdl.handle.net/2115/54865

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アクセス権
open access
URI
https://hdl.handle.net/2115/54865
タイトル
Magnetoencephalography localizing spike sources of atypical benign partial epilepsy
著者
Shiraishi, Hideaki ; Haginoya, Kazuhiro ; Nakagawa, Eiji ; Saitoh, Shinji ; Kaneko, Yutaka ; Nakasato, Nobukazu ; Chan, Derrick ; Otsubo, Hiroshi
e-Rad_Researcher
80374411
著者名
Shiraishi, Hideaki
著者名
Haginoya, Kazuhiro
著者名
Nakagawa, Eiji
著者名
Saitoh, Shinji
著者名
Kaneko, Yutaka
著者名
Nakasato, Nobukazu
著者名
Chan, Derrick
著者名
Otsubo, Hiroshi
言語
英語
キーワード
Epileptic negative myoclonus
Focal seizure
Atypical absence
Centro-temporal spike
Continuous spike and waves during sleep
Secondary bilateral synchrony
発行日
2014-01
出版者
Elsevier science bv
収録物名
Brain & development
巻(号)
36(1)
ページ
21-27
抄録
Rationale: Atypical benign partial epilepsy (ABPE) is characterized by centro-temporal electroencephalography (EEG) spikes, continuous spike and waves during sleep (CSWS), and multiple seizure types including epileptic negative myoclonus (ENM), but not tonic seizures. This study evaluated the localization of magnetoencephalography (MEG) spike sources (MEGSSs) to investigate the clinical features and mechanism underlying ABPE. Methods: We retrospectively analyzed seizure profiles, scalp video EEG (VEEG) and MEG in ABPE patients. Results: Eighteen ABPE patients were identified (nine girls and nine boys). Seizure onset ranged from 1.3 to 8.8 years (median, 2.9 years). Initial seizures consisted of focal motor seizures (15 patients) and absences/atypical absences (3). Seventeen patients had multiple seizure types including drop attacks (16), focal motor seizures (16), ENM (14), absences/atypical absences (11) and focal myoclonic seizures (10). VEEG showed centro-temporal spikes and CSWS in all patients. Magnetic resonance imaging (MRI) was reported as normal in all patients. MEGSSs were localized over the following regions: both Rolandic and sylvian (8), peri-sylvian (5), peri-Rolandic (4), parieto-occipital (1), bilateral (10) and unilateral (8). All patients were on more than two antiepileptic medications. ENM and absences/atypical absences were controlled in 14 patients treated with adjunctive ethosuximide. Conclusion: MEG localized the source of centro-temporal spikes and CSWS in the Rolandic-sylvian regions. Centro-temporal spikes, Rolandic-sylvian spike sources and focal motor seizures are evidence that ABPE presents with Rolandic-sylvian onset seizures. ABPE is therefore a unique, age-related and localization-related epilepsy with a Rolandic-sylvian epileptic focus plus possible thalamo-cortical epileptic networks in the developing brain of children.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0387-7604
NCID
AA00111153
関連情報
PMID
23384398
URI
http://www.sciencedirect.com/science/article/pii/S0387760413000041
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.braindev.2012.12.011