open access

https://hdl.handle.net/2115/54969

The molecular basis of induction and formation of tunneling nanotubes

英語

HIV Nef

2014-04-01

Springer-Verlag

Cell and Tissue Research

352(1)

67-76

Tunneling nanotubes (TNTs) and associated structures are recently recognized structures for intercellular communication. They are F-actin containing thin protrusions of the plasma membrane of a cell and allow a direct physical connection to the plasma membranes of remote cells. TNTs and associated structures serve as mediators for intercellular transfer of organelles as well as membrane components and cytoplasmic molecules. Moreover, several pathogens were shown to exploit these structures to spread among cells. Because of their contribution to normal cellular functions and importance in pathological conditions, studies on TNTs and related structures have accelerated over the past few years. These studies have revealed key molecules for their induction and/or formation; HIV Nef and M-Sec can induce the formation of TNTs in coordination with the remodeling of the actin cytoskeleton and vesicle trafficking.

学術雑誌論文

Accepted Manuscript

The final publication is available at www.springerlink.com

0302-766X

1432-0878