Lipoxygenase inhibitors derived from marine macroalgae

Kurihara, Hideyuki; Kagawa, Yoshio; Konno, Remi et al.

Bioorganic & medicinal chemistry letters, 2014, 24(5), 1383-1385

Permalink : https://hdl.handle.net/2115/55254

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アクセス権
open access
URI
https://hdl.handle.net/2115/55254
タイトル
Lipoxygenase inhibitors derived from marine macroalgae
著者
Kurihara, Hideyuki ; Kagawa, Yoshio ; Konno, Remi ; Kim, Sang Moo ; Takahashi, Koretaro
e-Rad_Researcher
40234570
著者名
Kurihara, Hideyuki
著者名
Kagawa, Yoshio
著者名
Konno, Remi
著者名
Kim, Sang Moo
e-Rad_Researcher
90125328
著者名
Takahashi, Koretaro
言語
英語
キーワード
Lipoxygenase
Inhibitor
Sargassum thunbergii
Alkapolyene
Odonthalia corymbifera
Pheophytin a
発行日
2014-03-01
出版者
Pergamon-elsevier science ltd
収録物名
Bioorganic & medicinal chemistry letters
巻(号)
24(5)
ページ
1383-1385
抄録
The solvent extracts from the algae Sargassum thunbergii (Sargassaceae) and Odonthalia corymbifera (Rhodomelaceae) were subjected to soybean lipoxygenase inhibitory screening. Two hydrophobic inhibitors were obtained from the extracts of S. thunbergii through inhibitory assay-guided fractionation. The inhibitors were identified as known exo-methylenic alkapolyenes (6Z, 9Z, 12Z, 15Z)-1,6,9,12,15-henicosapentaene (1) and (6Z, 9Z, 12Z, 15Z, 18Z)-1,6,9,12,15,18-henicosahexaene (2). The alkapolyenes 1 and 2 showed higher inhibitory activity than the known inhibitor nordihydroguaiaretic acid (NDGA). Pheophytin a (3) was obtained from the extract of O. corymbifera. The inhibitor 3 also showed higher inhibitory activity than NDGA. This is the first report on lipoxygenase inhibition of exo-methylenic alkapolyenes and a chlorophyll a-related substance. (C) 2014 Elsevier Ltd. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0960-894X
関連情報
PMID
24495846
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bmcl.2014.01.046