A Proton Beam Therapy System Dedicated to Spot-Scanning Increases Accuracy with Moving Tumors by Real-Time Imaging and Gating and Reduces Equipment Size

Shimizu, Shinichi; Miyamoto, Naoki; Matsuura, Taeko; Fujii, Yusuke; Umezawa, Masumi; Umegaki, Kikuo; Hiramoto, Kazuo; Shirato, Hiroki

A Proton Beam Therapy System Dedicated to Spot-Scanning Increases Accuracy with Moving Tumors by Real-Time Imaging and Gating and Reduces Equipment Size

Shimizu, Shinichi; Miyamoto, Naoki; Matsuura, Taeko et al.

PLoS ONE, 2014, 9(4), e94971

Permalink : https://hdl.handle.net/2115/56313

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アクセス権	open access
URI	https://hdl.handle.net/2115/56313
タイトル	A Proton Beam Therapy System Dedicated to Spot-Scanning Increases Accuracy with Moving Tumors by Real-Time Imaging and Gating and Reduces Equipment Size
著者	Shimizu, Shinichi ; Miyamoto, Naoki ; Matsuura, Taeko ; Fujii, Yusuke ; Umezawa, Masumi ; Umegaki, Kikuo ; Hiramoto, Kazuo ; Shirato, Hiroki
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
e-Rad_Researcher 00552879 著者名 Miyamoto, Naoki
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
著者名 Fujii, Yusuke
著者名 Umezawa, Masumi
e-Rad_Researcher 40643193 著者名 Umegaki, Kikuo
著者名 Hiramoto, Kazuo
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
発行日	2014-04-18
出版者	The Public Library of Science
収録物名	PLoS ONE
巻(号)	9(4)
ページ	e94971
抄録	PURPOSE: A proton beam therapy (PBT) system has been designed which dedicates to spot-scanning and has a gating function employing the fluoroscopy-based real-time-imaging of internal fiducial markers near tumors. The dose distribution and treatment time of the newly designed real-time-image gated, spot-scanning proton beam therapy (RGPT) were compared with free-breathing spot-scanning proton beam therapy (FBPT) in a simulation. MATERIALS AND METHODS: In-house simulation tools and treatment planning system VQA (Hitachi, Ltd., Japan) were used for estimating the dose distribution and treatment time. Simulations were performed for 48 motion parameters (including 8 respiratory patterns and 6 initial breathing timings) on CT data from two patients, A and B, with hepatocellular carcinoma and with clinical target volumes 14.6 cc and 63.1 cc. The respiratory patterns were derived from the actual trajectory of internal fiducial markers taken in X-ray real-time tumor-tracking radiotherapy (RTRT). RESULTS: With FBPT, 9/48 motion parameters achieved the criteria of successful delivery for patient A and 0/48 for B. With RGPT 48/48 and 42/48 achieved the criteria. Compared with FBPT, the mean liver dose was smaller with RGPT with statistical significance (p<0.001); it decreased from 27% to 13% and 28% to 23% of the prescribed doses for patients A and B, respectively. The relative lengthening of treatment time to administer 3 Gy (RBE) was estimated to be 1.22 (RGPT/FBPT: 138 s/113 s) and 1.72 (207 s/120 s) for patients A and B, respectively. CONCLUSIONS: This simulation study demonstrated that the RGPT was able to improve the dose distribution markedly for moving tumors without very large treatment time extension. The proton beam therapy system dedicated to spot-scanning with a gating function for real-time imaging increases accuracy with moving tumors and reduces the physical size, and subsequently the cost of the equipment as well as of the building housing the equipment.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
EISSN	1932-6203
関連情報	PMID 24747601
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0094971