Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-Risk Stratification for Application of Radiotherapy

Yamaguchi, Shigeru; Terasaka, Shunsuke; Kobayashi, Hiroyuki; Asaoka, Katsuyuki; Motegi, Hiroaki; Nishihara, Hiroshi; Kanno, Hiromi; Onimaru, Rikiya; Ito, Yoichi M.; Shirato, Hiroki; Houkin, Kiyohiro

Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-Risk Stratification for Application of Radiotherapy

Yamaguchi, Shigeru; Terasaka, Shunsuke; Kobayashi, Hiroyuki et al.

PLOS One, 2014, 9(5), e97108

Permalink : https://hdl.handle.net/2115/56606

このアイテムのアクセス数:1,039件（2026-10-12 19:03 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
PLoS One_9(5)_e97108	pdf	356 KB	816

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/56606
タイトル	Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-Risk Stratification for Application of Radiotherapy
著者	Yamaguchi, Shigeru ; Terasaka, Shunsuke ; Kobayashi, Hiroyuki ; Asaoka, Katsuyuki ; Motegi, Hiroaki ; Nishihara, Hiroshi ; Kanno, Hiromi ; Onimaru, Rikiya ; Ito, Yoichi M. ; Shirato, Hiroki ; Houkin, Kiyohiro
著者名 Yamaguchi, Shigeru
e-Rad_Researcher 10447055 著者名 Terasaka, Shunsuke
著者名 Kobayashi, Hiroyuki
著者名 Asaoka, Katsuyuki
著者名 Motegi, Hiroaki
e-Rad_Researcher 50322805 著者名 Nishihara, Hiroshi
著者名 Kanno, Hiromi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
著者名 Ito, Yoichi M.
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 90229146 著者名 Houkin, Kiyohiro
言語	英語
発行日	2014-05-12
出版者	Public Library of Science
収録物名	PLOS One
巻(号)	9(5)
ページ	e97108
抄録	Background: Radiotherapy for high-grade meningioma (HGM) is one of the essential treatment options for disease control. However, appropriate irradiation timing remains under debate. The object of this study is to discern which prognostic factors impact recurrence in HGM patients and to propose a risk-stratification system for the application of postoperative radiotherapy. Methods: We retrospectively reviewed 55 adult patients who were diagnosed with Grade II and III intracranial meningioma. Cox regression models were applied to the analysis for impact on early recurrence in HGM patients without postoperative radiotherapy. Results: Grade III malignancy (P = 0.0073) and transformed histology (P = 0.047) proved to be significantly poor prognostic factors of early recurrence by multivariate analysis. The other candidates for recurrence factors were Simpson Grade 3-5 resection, preoperative Karnofsky Performance status, <= 70%, and MIB-1 labeling index >= 15%. According to these prognostic factors, postoperative HGM patients could be stratified into three recurrence-risk groups. The prognoses were significantly different between each group, as the 3-year actual recurrence-free rates were 90% in low-risk group, 31% in intermediate-risk group, and 15% in high-risk group. Conclusion: We propose recurrence-risk stratification for postoperative HGM patients using clinically available factors. Our results suggest that the prognosis for patients with high-risk HGMs is dismal, whereas HGM patients belonging to the low-risk group could have favorable prognoses. This stratification provides us with the criteria necessary to determine whether to apply adjuvant radiotherapy to postoperative HGM patients, and to also help identify potentially curable HGMs without adjuvant radiotherapy.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	1932-6203
関連情報	PMID 24820480
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0097108