Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter

Kawamura, Eriko; Yamada, Yuma; Harashima, Hideyoshi

Mitochondrion, 2013, 13(6), 610-614

Permalink : https://hdl.handle.net/2115/56636

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アクセス権
open access
URI
https://hdl.handle.net/2115/56636
タイトル
Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter
著者
Kawamura, Eriko ; Yamada, Yuma ; Harashima, Hideyoshi
著者名
Kawamura, Eriko
e-Rad_Researcher
60451431
著者名
Yamada, Yuma
e-Rad_Researcher
00183567
著者名
Harashima, Hideyoshi
言語
英語
キーワード
Mitochondria
Mitochondrial drug delivery
Mitochondrial targeting peptide
MITO-Porter
S2 peptide
Nanoparticles
発行日
2013-11
出版者
Elsevier sci ltd
収録物名
Mitochondrion
巻(号)
13(6)
ページ
610-614
抄録
To achieve mitochondrial therapy, we previously reported on the use of an octaarginine (R8) modified Dual Function (DF)-MITO-Porter for delivering molecules to mitochondria in living cells. In this study, using isolated mitochondria, homogenates and living cells, we evaluated the utility of mitochondrial targeting functional peptides as a ligand for delivering carriers. The S2 peptide modified carrier showed a high mitochondrial targeting activity in homogenates and living cells. In addition, the S2 peptide had a lower cell toxicity compared to R8 modified liposomes. The S2 peptide represents a potentially useful moiety for constructing an efficient and safe mitochondrial delivery system. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
1567-7249
関連情報
PMID
24012978
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.mito.2013.08.010