Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Koyama, Motoko; Hashimoto, Daigo; Nagafuji, Koji; Eto, Tetsuya; Ohno, Yuju; Aoyama, Kazutoshi; Iwasaki, Hiromi; Miyamoto, Toshihiro; Hill, Geoffrey R.; Akashi, Koichi; Teshima, Takanori

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Koyama, Motoko; Hashimoto, Daigo; Nagafuji, Koji et al.

Bone Marrow Transplantation, 2014, 49(1), 110-115

Permalink : https://hdl.handle.net/2115/56649

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アクセス権	open access
URI	https://hdl.handle.net/2115/56649
タイトル	Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning
著者	Koyama, Motoko ; Hashimoto, Daigo ; Nagafuji, Koji ; Eto, Tetsuya ; Ohno, Yuju ; Aoyama, Kazutoshi ; Iwasaki, Hiromi ; Miyamoto, Toshihiro ; Hill, Geoffrey R. ; Akashi, Koichi ; Teshima, Takanori
著者名 Koyama, Motoko
著者名 Hashimoto, Daigo
著者名 Nagafuji, Koji
著者名 Eto, Tetsuya
著者名 Ohno, Yuju
著者名 Aoyama, Kazutoshi
著者名 Iwasaki, Hiromi
著者名 Miyamoto, Toshihiro
著者名 Hill, Geoffrey R.
著者名 Akashi, Koichi
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	graft rejection
	bone marrow transplantation
	cord blood transplantation
発行日	2014-01
出版者	Nature Publishing Group
収録物名	Bone Marrow Transplantation
巻(号)	49(1)
ページ	110-115
抄録	Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0268-3369
EISSN	1476-5365
NCID	AA10673987
関連情報	PMID 24013691
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/bmt.2013.134