TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer

Kanno, Yukiko; Watanabe, Masashi; Kimura, Taichi; Nonomura, Katsuya; Tanaka, Shinya; Hatakeyama, Shigetsugu

TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer

Kanno, Yukiko; Watanabe, Masashi; Kimura, Taichi et al.

Acta Histochemica, 2014, 116(5), 708-712

Permalink : https://hdl.handle.net/2115/56976

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アクセス権	open access
URI	https://hdl.handle.net/2115/56976
タイトル	TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer
著者	Kanno, Yukiko ; Watanabe, Masashi ; Kimura, Taichi ; Nonomura, Katsuya ; Tanaka, Shinya ; Hatakeyama, Shigetsugu
著者名 Kanno, Yukiko
著者名 Watanabe, Masashi
e-Rad_Researcher 90435959 著者名 Kimura, Taichi
e-Rad_Researcher 60113750 著者名 Nonomura, Katsuya
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	TRIM29
	Prostate cancer
	Basal cell
	Human
発行日	2014-06
出版者	Elsevier
収録物名	Acta Histochemica
巻(号)	116(5)
ページ	708-712
抄録	Tripartite motif protein 29 (TRIM29) is one of the TRIM family proteins, some of which function as E3 ubiquitin ligases. In this study, we investigated the usefulness of TRIM29 for diagnosis of prostate cancer Prostate tissues including carcinoma and non-carcinoma tissues obtained by needle biopsy and radical prostatectomy were used. Immunohistochemistry was performed according to standard procedures using an antibody against TRIM29. Immunohistochemical staining with an antibody against 34 beta E12, which recognizes cytokeratins 1, 5, 10 and 14, was performed as a control. Basal cells of normal prostatic glands were stained with anti-TRIM29 antibody in all cases, whereas prostate cancer tissues had no or little staining with anti-TRIM29 antibody. TRIM29 is selectively expressed in basal cells of the normal prostate gland, and immunohistochemical staining with anti-TRIM29 antibody showed the same expression pattern as that with 34 beta E12 in prostate cancer and its benign mimics. Our data indicate that TRIM29 may be useful for distinguishing prostate cancers from benign tissues. (C) 2013 Elsevier GmbH. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0065-1281
NCID	AA00508000
関連情報	PMID 24485335
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.acthis.2013.12.009