Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Matsui, Yuki; Tomaru, Utano; Miyoshi, Arina; Ito, Tomoki; Fukaya, Shinji; Miyoshi, Hideaki; Atsumi, Tatsuya; Ishizu, Akihiro

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Matsui, Yuki; Tomaru, Utano; Miyoshi, Arina et al.

Experimental and Molecular Pathology, 2014, 97(3), 354-358

Permalink : https://hdl.handle.net/2115/57002

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/57002
タイトル	Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet
著者	Matsui, Yuki ; Tomaru, Utano ; Miyoshi, Arina ; Ito, Tomoki ; Fukaya, Shinji ; Miyoshi, Hideaki ; Atsumi, Tatsuya ; Ishizu, Akihiro
著者名 Matsui, Yuki
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
著者名 Miyoshi, Arina
著者名 Ito, Tomoki
著者名 Fukaya, Shinji
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
言語	英語
キーワード	Adipose tissue inflammation
	High fat diet
	Obesity
	TACE
	TNF-α
発行日	2014-12
出版者	Elsevier
収録物名	Experimental and Molecular Pathology
巻(号)	97(3)
ページ	354-358
抄録	Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of the so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-4800
関連情報	PMID 25236578
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.yexmp.2014.09.017