Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2

Miyaji, Hirofumi; Yokoyama, Hiroyuki; Kosen, Yuta; Nishimura, Hiroyuki; Nakane, Kazuyasu; Tanaka, Saori; Otani, Kaori; Inoue, Kana; Ibara, Asako; Kanayama, Izumi; Yoshida, Takashi; Ogawa, Kosuke; Nishida, Erika; Kawanami, Masamitsu

Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2

Miyaji, Hirofumi; Yokoyama, Hiroyuki; Kosen, Yuta et al.

J Oral Tissue Engin, 2013, 10(3), 172-181

Permalink : https://hdl.handle.net/2115/57045

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アクセス権	open access
URI	https://hdl.handle.net/2115/57045
タイトル	Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-2
著者	Miyaji, Hirofumi ; Yokoyama, Hiroyuki ; Kosen, Yuta ; Nishimura, Hiroyuki ; Nakane, Kazuyasu ; Tanaka, Saori ; Otani, Kaori ; Inoue, Kana ; Ibara, Asako ; Kanayama, Izumi ; Yoshida, Takashi ; Ogawa, Kosuke ; Nishida, Erika ; Kawanami, Masamitsu
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
著者名 Yokoyama, Hiroyuki
著者名 Kosen, Yuta
著者名 Nishimura, Hiroyuki
著者名 Nakane, Kazuyasu
e-Rad_Researcher 90344522 著者名 Tanaka, Saori
著者名 Otani, Kaori
著者名 Inoue, Kana
著者名 Ibara, Asako
著者名 Kanayama, Izumi
著者名 Yoshida, Takashi
著者名 Ogawa, Kosuke
著者名 Nishida, Erika
e-Rad_Researcher 10133761 著者名 Kawanami, Masamitsu
言語	英語
キーワード	bone tissue engineering
	beta-tricalcium phosphate (β-TCP)
	regenerative scaffold
	fibroblast growth factor-2 (FGF2)
	open-cell structure
発行日	2013-03-30
出版者	日本再生歯科医学会
収録物名	J Oral Tissue Engin
巻(号)	10(3)
ページ	172-181
抄録	We prepared highly porous beta-tricalcium phosphate (β-TCP) scaffolds with different open-cell structure sizes. The aim of this study was to examine whether the open-cell size of the scaffold affected osteoinduction in combination with fibroblast growth factor-2 (FGF2) in rats. Polyurethane foam was immersed in β-TCP slurry and sintered in a furnace. Porous β-TCP scaffolds were prepared in three cell sizes (0.6, 0.4 and 0.3 mm) and characterized. Subsequently, each scaffold with FGF2 was implanted to rat cranial bone. Histomorphometric analyses were taken at 35 days post-surgery. The results showed that each β-TCP scaffold exhibited fully interconnected porosity, and frequently allowed bone tissue ingrowth. The 0.4-mm cell sized scaffold significantly promoted bone augmentation compared to the 0.3-mm type. Resorption of the β-TCP scaffold of 0.4-mm cell size was frequently accelerated. In conclusion, FGF2-loaded β-TCP scaffolds with 0.4-mm cell size would be effective for bone tissue engineering.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	日本再生歯科医学会(利用は著作権の範囲内に限られます)
PISSN	1348-9623
NCID	AA1195240X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.11223/jarde.10.172