Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas

Sakashita, Tomohiro; Homma, Akihiro; Suzuki, Seigo; Hatakeyama, Hiromitsu; Kano, Satoshi; Mizumachi, Takatsugu; Oridate, Nobuhiko; Fukuda, Satoshi

Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas

Sakashita, Tomohiro; Homma, Akihiro; Suzuki, Seigo et al.

Acta oto-laryngologica, 2013, 133(9), 984-991

Permalink : https://hdl.handle.net/2115/57076

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アクセス権	open access
URI	https://hdl.handle.net/2115/57076
タイトル	Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas
著者	Sakashita, Tomohiro ; Homma, Akihiro ; Suzuki, Seigo ; Hatakeyama, Hiromitsu ; Kano, Satoshi ; Mizumachi, Takatsugu ; Oridate, Nobuhiko ; Fukuda, Satoshi
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 00399891 著者名 Suzuki, Seigo
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
著者名 Mizumachi, Takatsugu
e-Rad_Researcher 90312355 著者名 Oridate, Nobuhiko
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	Immunohistochemistry
	local recurrence
	head and neck cancer
発行日	2013-09
出版者	Informa
収録物名	Acta oto-laryngologica
巻(号)	133(9)
ページ	984-991
抄録	Conclusion: It was proved that cyclin D1-positive status in surgical margins was an independent prognostic indicator of local recurrence. The expression of cyclin D1 in tumor-free surgical margins may better predict local recurrence in patients with head and neck squamous cell carcinoma (HNSCC) after surgical treatment with curative intent. Objective: This retrospective study aimed to determine the prognostic indicators for local recurrence in HNSCC. Methods: A total of 116 HNSCC patients who underwent surgical treatment with curative intent and had histopathologically tumor-free margins were eligible for this study. The expression of p53 and cyclin D1 was assessed by immunohistochemical staining in surgical margins as well as in tumor specimens. Results: In all, 63 patients (54.3%) had p53-positive tumor specimens and 34 patients (29.3%) had p53-positive margins. Seventy-six patients (65.6%) had cyclin D1-positive tumor specimens and 54 patients (46.6%) had cyclin D1-positive margins. A significant difference in local control rates was observed between patients with cyclin D1-positive and -negative margins (77.2% vs 91.5%, log rank test, p = 0.0139). Multivariate Cox proportional hazards testing indicated that the hazard ratio of cyclin D1-positive margins for local recurrence was 4.58 (95% confidence interval 1.14–21.69, p = 0.0304).
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright (c) Informa
PISSN	1651-2251
関連情報	PMID 23692432
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.3109/00016489.2013.795287