Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine

Kobayashi, Shingo; Yoneda, Atushi; Fukuhara, Tsuyoshi et al.

Tetrahedron, 2004, 60(32), 6923-6930

Permalink : https://hdl.handle.net/2115/575

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アクセス権	open access
URI	https://hdl.handle.net/2115/575
タイトル	Deoxyfluorination of alcohols using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine
著者	Kobayashi, Shingo ; Yoneda, Atushi ; Fukuhara, Tsuyoshi ; Hara, Shoji
著者名 Kobayashi, Shingo
著者名 Yoneda, Atushi
著者名 Fukuhara, Tsuyoshi
e-Rad_Researcher 20109490 著者名 Hara, Shoji 原, 正治
言語	英語
キーワード	Deoxyfluorination
	DFMBA
	Fluoro sugars
	Microwave
発行日	2004-08-02
出版者	Elsevier
収録物名	Tetrahedron
巻(号)	60(32)
ページ	6923-6930
抄録	Deoxyfluorination of alcohols was carried out using N,N-diethyl-α,α-difluoro-(m-methylbenzyl)amine (DFMBA). Primary alcohols were effectively converted to fluorides under microwave irradiation or conventional heating. Deoxyfluorination of an anomeric hydroxy group in sugars by DFMBA proceeded at below room temperature and glycosyl fluorides could be obtained in good yields. The deoxyfluorination reaction chemoselectively proceeded and various protecting groups on the sugar can survive under the reaction conditions.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	00404020
関連情報	URI http://www.sciencedirect.com/science/journal/00404020
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tet.2004.05.089