Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis

Tamura, Yu; Ohta, Hiroshi; Yokoyama, Nozomu; Lim, Sue Yee; Osuga, Tatsuyuki; Morishita, Keitaro; Nakamura, Kensuke; Yamasaki, Masahiro; Takiguchi, Mitsuyoshi

Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis

Tamura, Yu; Ohta, Hiroshi; Yokoyama, Nozomu et al.

Journal of Veterinary Medical Science, 2014, 76(10), 1407-1410

Permalink : https://hdl.handle.net/2115/57535

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アクセス権	open access
URI	https://hdl.handle.net/2115/57535
タイトル	Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis
著者	Tamura, Yu ; Ohta, Hiroshi ; Yokoyama, Nozomu ; Lim, Sue Yee ; Osuga, Tatsuyuki ; Morishita, Keitaro ; Nakamura, Kensuke ; Yamasaki, Masahiro ; Takiguchi, Mitsuyoshi
著者名 Tamura, Yu
e-Rad_Researcher 50431333 著者名 Ohta, Hiroshi
著者名 Yokoyama, Nozomu
著者名 Lim, Sue Yee
著者名 Osuga, Tatsuyuki
e-Rad_Researcher 30637046 著者名 Morishita, Keitaro
著者名 Nakamura, Kensuke
e-Rad_Researcher 40322846 著者名 Yamasaki, Masahiro
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	canine
	colon
	cytokine
	lymphocytic-plasmacytic colitis
	mRNA
発行日	2014-10
出版者	Japanese Society of Veterinary Science
収録物名	Journal of Veterinary Medical Science
巻(号)	76(10)
ページ	1407-1410
抄録	Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-gamma, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha., IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
PISSN	0916-7250
NCID	AA10796138
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.13-0635