Effect of antispasmodic drugs on endoscopic ultrasound/endoscopic ultrasound-guided fine-needle aspiration : A multicenter randomized controlled trial

Kuwatani, Masaki; Kawakami, Hiroshi; Hayashi, Tsuyoshi; Eto, Kazunori; Yamato, Hiroaki; Onodera, Manabu; Naruse, Hirohito; Oba, Koji

Effect of antispasmodic drugs on endoscopic ultrasound/endoscopic ultrasound-guided fine-needle aspiration : A multicenter randomized controlled trial

Kuwatani, Masaki; Kawakami, Hiroshi; Hayashi, Tsuyoshi et al.

Endoscopic Ultrasound, 2014, 3(3), 167-173

Permalink : https://hdl.handle.net/2115/57557

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アクセス権	open access
URI	https://hdl.handle.net/2115/57557
タイトル	Effect of antispasmodic drugs on endoscopic ultrasound/endoscopic ultrasound-guided fine-needle aspiration : A multicenter randomized controlled trial
著者	Kuwatani, Masaki ; Kawakami, Hiroshi ; Hayashi, Tsuyoshi ; Eto, Kazunori ; Yamato, Hiroaki ; Onodera, Manabu ; Naruse, Hirohito ; Oba, Koji
e-Rad_Researcher 50431375 著者名 Kuwatani, Masaki
e-Rad_Researcher 80399823 著者名 Kawakami, Hiroshi
e-Rad_Researcher 60381258 著者名 Hayashi, Tsuyoshi
著者名 Eto, Kazunori
著者名 Yamato, Hiroaki
著者名 Onodera, Manabu
著者名 Naruse, Hirohito
e-Rad_Researcher 30422926 著者名 Oba, Koji
言語	英語
キーワード	Antispasmodic drug
	endoscopic ultrasonography
	endoscopic ultrasound-guided fine-needle aspiration
	examination time
発行日	2014
出版者	Medknow
収録物名	Endoscopic Ultrasound
巻(号)	3(3)
ページ	167-173
抄録	Background and Objective: Antispasmodic drugs (ADs) have been used to reduce examination time or improve the quality of gastrointestinal endoscopy, although the practice is controversial. No evidence about the efficacy of AD for endoscopic ultrasonography/EUS-guided fine-needle aspiration (EUS/EUS-FNA) is available. This study was aimed to evaluate the efficacy of AD in EUS/EUS-FNA. Patients and Methods: A total of 400 patients with pancreaticobiliary, peripancreatic, or peribiliary disease or disorder undergoing EUS/EUS-FNA were prospectively and evenly randomized to undergo EUS/EUS-FNA with AD (w-AD) or without AD (w/o-AD). The primary endpoint was total EUS/EUS-FNA examination time. The secondary endpoints were visual analogue scale (VAS) scores of endoscopists (patient body motion, gastrointestinal peristalsis, and accomplishment of the purpose) and patients (pain, discomfort, and willingness to undergo re-examination), vital sign changes, adverse events, and sedative dose. Results: Two hundred patients in the w-AD group and 197 patients in the w/o-AD group were ultimately analyzed. The total examination time was similar between the groups (2299 ± 937 vs. 2259 ± 1019 s). The difference in total examination time from w/o-AD group to w-AD group was −40 s (95% confidence interval, −234-153 s), which was within the noninferiority margin. No statistical differences were observed in endoscopist and patient VAS scores, changes in vital signs, adverse events, or total sedative dose other than fentanyl between the groups. Conclusion: EUS/EUS-FNA can be effectively and safely performed w/o-AD. Further, randomized controlled trials on EUS/EUS-FNA in various disease entities may be required to confirm the results of this study (UMIN000008047).
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
PISSN	2303-9027
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.4103/2303-9027.138788