A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide

Yuyama, Kohei; Sun, Hui; Usuki, Seigo; Sakai, Shota; Hanamatsu, Hisatoshi; Mioka, Tetsuo; Kimura, Nobuyuki; Okada, Megumi; Tahara, Hidetoshi; Furukawa, Jun-ichi; Fujitani, Naoki; Shinohara, Yasuro; Igarashi, Yasuyuki

A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide

Yuyama, Kohei; Sun, Hui; Usuki, Seigo et al.

FEBS letters, 2015, 589(1), 84-88

Permalink : https://hdl.handle.net/2115/57841

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アクセス権	open access
URI	https://hdl.handle.net/2115/57841
タイトル	A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide
著者	Yuyama, Kohei ; Sun, Hui ; Usuki, Seigo ; Sakai, Shota ; Hanamatsu, Hisatoshi ; Mioka, Tetsuo ; Kimura, Nobuyuki ; Okada, Megumi ; Tahara, Hidetoshi ; Furukawa, Jun-ichi ; Fujitani, Naoki ; Shinohara, Yasuro ; Igarashi, Yasuyuki
e-Rad_Researcher 80415546 著者名 Yuyama, Kohei
著者名 Sun, Hui
著者名 Usuki, Seigo
著者名 Sakai, Shota
著者名 Hanamatsu, Hisatoshi
著者名 Mioka, Tetsuo
著者名 Kimura, Nobuyuki
著者名 Okada, Megumi
著者名 Tahara, Hidetoshi
著者名 Furukawa, Jun-ichi
e-Rad_Researcher 10374191 著者名 Fujitani, Naoki
著者名 Shinohara, Yasuro
e-Rad_Researcher 70091965 著者名 Igarashi, Yasuyuki
言語	英語
キーワード	Exosome
	Amyloid-beta peptide
	Alzheimer's disease
	Cynomolgus monkey
	APP transgenic mouse
	Cerebrospinal fluid
発行日	2015-01-02
出版者	Elsevier
収録物名	FEBS letters
巻(号)	589(1)
ページ	84-88
抄録	Elevated amyloid-beta peptide (A beta) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome-associated A beta in the cerebrospinal fluid (CSF) of cynomolgus monkeys and APP transgenic mice. The levels of exosome-associated A beta notably decreased in the CSF of aging animals. We also determined that neuronal exosomes, but not glial exosomes, had abundant glycosphingolipids and could capture A beta. Infusion of neuronal exosomes into brains of APP transgenic mice decreased A beta and amyloid depositions, similarly to what reported previously on neuroblastoma-derived exosomes. These findings highlight the role of neuronal exosomes in A beta clearance, and suggest that their downregulation might relate to Ab accumulation and, ultimately, the development of AD pathology. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-5793
関連情報	PMID 25436414
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.febslet.2014.11.027