Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma

Kato, Yasutaka; Nishihara, Hiroshi; Mohri, Hiromi et al.

Brain tumor pathology, 2014, 31(1), 23-30

Permalink : https://hdl.handle.net/2115/57872

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アクセス権
open access
URI
https://hdl.handle.net/2115/57872
タイトル
Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma
著者
Kato, Yasutaka ; Nishihara, Hiroshi ; Mohri, Hiromi ; Kanno, Hiromi ; Kobayashi, Hiroyuki ; Kimura, Taichi ; Tanino, Mishie ; Terasaka, Shunsuke ; Tanaka, Shinya
著者名
Kato, Yasutaka
e-Rad_Researcher
50322805
著者名
Nishihara, Hiroshi
著者名
Mohri, Hiromi
著者名
Kanno, Hiromi
著者名
Kobayashi, Hiroyuki
e-Rad_Researcher
90435959
著者名
Kimura, Taichi
e-Rad_Researcher
90360908
著者名
Tanino, Mishie
e-Rad_Researcher
10447055
著者名
Terasaka, Shunsuke
e-Rad_Researcher
70261287
著者名
Tanaka, Shinya
言語
英語
キーワード
Cyclooxygenase-2
Meningioma
Immunohistochemistry
Clinicopathological analysis
発行日
2014-01
出版者
Springer Japan
収録物名
Brain tumor pathology
巻(号)
31(1)
ページ
23-30
抄録
Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors. We evaluated expression of COX-2 in meningioma, one of the most common intracranial tumors in adults which accounts for 24-30 % of intracranial tumors. We performed immunostaining for COX-2 in 76 cases of meningioma consisting of 44 cases of low-grade (WHO Grade I) and 32 cases of high-grade (29 cases of Grade II and 3 cases of Grade III) meningioma, and evaluated COX-2 expression levels on the basis of staining intensity and proportion in tumor cells. The expression level of COX-2 in meningioma cells was significantly correlated with WHO grade (P = 0.0153). In addition, COX-2 expression was significantly correlated with MIB-1 labeling index for all 76 cases of meningioma (P = 0.0075), suggesting tumor promotion by COX-2 in meningioma progression. Our results may indicate the therapeutic value of non-steroidal anti-inflammatory drugs against meningioma, especially for patients with elevated proliferation, to regulate the tumorigenic activity of COX-2 in meningioma cells.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The final publication is available at link.springer.com
PISSN
1433-7398
NCID
AA11203151
関連情報
PMID
23250387
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s10014-012-0127-8