A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

Ishii, Akihiro; Ueno, Keisuke; Orba, Yasuko; Sasaki, Michihito; Moonga, Ladslav; Hang'ombe, Bernard M.; Mweene, Aaron S.; Umemura, Takashi; Ito, Kimihito; Hall, William W.; Sawa, Hirofumi

A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

Ishii, Akihiro; Ueno, Keisuke; Orba, Yasuko et al.

Nature communications, 2014, 5, 5651

Permalink : https://hdl.handle.net/2115/57925

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アクセス権	open access
URI	https://hdl.handle.net/2115/57925
タイトル	A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice
著者	Ishii, Akihiro ; Ueno, Keisuke ; Orba, Yasuko ; Sasaki, Michihito ; Moonga, Ladslav ; Hang'ombe, Bernard M. ; Mweene, Aaron S. ; Umemura, Takashi ; Ito, Kimihito ; Hall, William W. ; Sawa, Hirofumi
e-Rad_Researcher 90421982 著者名 Ishii, Akihiro
e-Rad_Researcher 90435983 著者名 Ueno, Keisuke
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
著者名 Moonga, Ladslav
著者名 Hang'ombe, Bernard M.
著者名 Mweene, Aaron S.
e-Rad_Researcher 00151936 著者名 Umemura, Takashi
e-Rad_Researcher 60396314 著者名 Ito, Kimihito
著者名 Hall, William W.
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
言語	英語
発行日	2014-12
出版者	Nature Publishing Group
収録物名	Nature communications
巻(号)	5
ページ	5651
抄録	Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. This nairovirus infection is highly prevalent among giant leaf-nosed bats, Hipposideros gigas (detected in samples from 16 individuals out of 38). Whole-genome analysis of three viral isolates (11SB17, 11SB19 and 11SB23) reveals a typical bunyavirus tri-segmented genome. The strains form a single phylogenetic clade that is divergent from other known nairoviruses, and are hereafter designated as Leopards Hill virus (LPHV). When i.p. injected into mice, the 11SB17 strain causes only slight body weight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Crimean-Congo Haemorrhagic Fever virus in humans. We believe that our LPHV mouse model will be useful for research on the pathogenesis of nairoviral haemorrhagic disease.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2041-1723
NCID	AA12645905
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/ncomms6651