A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Kon, Shigeyuki; Nakayama, Yosuke; Matsumoto, Naoki; Ito, Koyu; Kanayama, Masashi; Kimura, Chiemi; Kouro, Hitomi; Ashitomi, Dai; Matsuda, Tadashi; Uede, Toshimitsu

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Kon, Shigeyuki; Nakayama, Yosuke; Matsumoto, Naoki et al.

PLOS one, 2014, 9(12), e116210

Permalink : https://hdl.handle.net/2115/57930

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アクセス権	open access
URI	https://hdl.handle.net/2115/57930
タイトル	A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis
著者	Kon, Shigeyuki ; Nakayama, Yosuke ; Matsumoto, Naoki ; Ito, Koyu ; Kanayama, Masashi ; Kimura, Chiemi ; Kouro, Hitomi ; Ashitomi, Dai ; Matsuda, Tadashi ; Uede, Toshimitsu
e-Rad_Researcher 90344499 著者名 Kon, Shigeyuki
著者名 Nakayama, Yosuke
著者名 Matsumoto, Naoki
著者名 Ito, Koyu
著者名 Kanayama, Masashi
著者名 Kimura, Chiemi
著者名 Kouro, Hitomi
著者名 Ashitomi, Dai
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
e-Rad_Researcher 00160185 著者名 Uede, Toshimitsu
言語	英語
発行日	2014-12-29
出版者	Public Library of Science
収録物名	PLOS one
巻(号)	9(12)
ページ	e116210
抄録	Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation is the production of various functional fragments by enzyme cleavage. It has been well appreciated that OPN is cleaved by thrombin, and/or matrix metalloproteinase-3 and -7 (MMP-3/7). Although the function of thrombin-cleaved OPN is well characterized, little is known about the function of MMP-3/7-cleaved OPN. In this study, we found a novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to alpha 9b1 integrin. Importantly, this novel motif is involved in the development of anti-type II collagen antibody-induced arthritis (CAIA). This study provides the first in vitro and in vivo evidence that OPN cleavage by MMP-3/7 is an important regulatory mechanism for CAIA.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報	PMID 25545242
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0116210