Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival

Kudo, Hiroya; Wada, Haruka; Sasaki, Hajime et al.

PLOS one, 2014, 9(10), e111826

Permalink : https://hdl.handle.net/2115/57942

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アクセス権
open access
URI
https://hdl.handle.net/2115/57942
タイトル
Induction of Macrophage-Like Immunosuppressive Cells from Mouse ES Cells That Contribute to Prolong Allogeneic Graft Survival
著者
Kudo, Hiroya ; Wada, Haruka ; Sasaki, Hajime ; Tsuji, Hyuma ; Otsuka, Ryo ; Baghdadi, Muhammad ; Kojo, Satoshi ; Chikaraishi, Tatsuya ; Seino, Ken-ichiro
著者名
Kudo, Hiroya
e-Rad_Researcher
70392181
著者名
Wada, Haruka
著者名
Sasaki, Hajime
著者名
Tsuji, Hyuma
著者名
Otsuka, Ryo
著者名
Baghdadi, Muhammad
e-Rad_Researcher
70360542
著者名
Kojo, Satoshi
e-Rad_Researcher
80261303
著者名
Chikaraishi, Tatsuya
著者名
Seino, Ken-ichiro
言語
英語
発行日
2014-10-30
出版者
Public Library of Science
収録物名
PLOS one
巻(号)
9(10)
ページ
e111826
抄録
Recent progress in regenerative medicine has enabled the utilization of pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) as a donor resource for transplantation. However, immune suppression is still needed when the donor-recipient combination is allogeneic. Protection of ESCs-derived grafts from host immune response might be achieved thought the utilization of immunosuppressive cells generated from ESCs. In the present study, we show that a certain fraction of immunosuppressive cells can be generated from ESCs and help to suppress immune response against allogeneic grafts. ESCs-derived suppressor cells (ES-SCs) resembled macrophages in terms of cell surface molecule and gene expressions. Furthermore, gene expression analysis including microarray showed that ES-SCs have M1/M2 hybrid phenotype with high expression of genes correlated to immunosuppression of T cell response. Indeed, ES-SCs were effective to block allogeneic T cell proliferation in a nitric oxide-dependent manner, and prolonged the survival of ESCs-derived embryoid bodies or cardiomyocytes grafts transplanted into mouse kidney capsule. Thus, we consider the potential use of these ESCs-derived macrophage-like immunosuppressive cells as cellular therapies to promote long-term graft survival in future therapies.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1932-6203
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1371/journal.pone.0111826