Autophagy in the placenta of women with hypertensive disorders in pregnancy

Akaishi, Rina; Yamada, Takahiro; Nakabayashi, Kazuhiko; Nishihara, Hiroshi; Furuta, Itsuko; Kojima, Takashi; Morikawa, Mamoru; Yamada, Takashi; Fujita, Naonobu; Minakami, Hisanori

Autophagy in the placenta of women with hypertensive disorders in pregnancy

Akaishi, Rina; Yamada, Takahiro; Nakabayashi, Kazuhiko et al.

Placenta, 2014, 35(12), 974-980

Permalink : https://hdl.handle.net/2115/57971

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アクセス権	open access
URI	https://hdl.handle.net/2115/57971
タイトル	Autophagy in the placenta of women with hypertensive disorders in pregnancy
著者	Akaishi, Rina ; Yamada, Takahiro ; Nakabayashi, Kazuhiko ; Nishihara, Hiroshi ; Furuta, Itsuko ; Kojima, Takashi ; Morikawa, Mamoru ; Yamada, Takashi ; Fujita, Naonobu ; Minakami, Hisanori
著者名 Akaishi, Rina
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
e-Rad_Researcher 10415557 著者名 Nakabayashi, Kazuhiko
e-Rad_Researcher 50322805 著者名 Nishihara, Hiroshi
e-Rad_Researcher 70238682 著者名 Furuta, Itsuko
著者名 Kojima, Takashi
e-Rad_Researcher 00374380 著者名 Morikawa, Mamoru
e-Rad_Researcher 20374283 著者名 Yamada, Takashi
e-Rad_Researcher 00506496 著者名 Fujita, Naonobu
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	Autophagy
	Gestational hypertension
	Preeclampsia
	Pregnancy-induced hypertension
発行日	2014-12
出版者	Elsevier
収録物名	Placenta
巻(号)	35(12)
ページ	974-980
抄録	Introduction: Autophagy has not been studied extensively in the human placenta. This study was performed to determine whether autophagy is increased in the placentas of women with hypertensive disorders in pregnancy compared to normotensive pregnancies. Methods: LC3-II and p62 protein expression were examined by quantitative Western blotting analysis in 40 placentas from women not experiencing labor pains. The 40 placentas were from 13, 8, and 19 women with preeclampsia, gestational hypertension, and normal pregnancy, respectively. Hypertensive disorders in pregnancy included preeclampsia and gestational hypertension. Results: LC3-II expression was significantly increased, while that of p62 was significantly reduced in 21 placentas of women with hypertensive disorders compared to those with normal blood pressure irrespective of the presence or absence of fetal growth restriction (FGR). LC3-II expression was also significantly increased in 13 placentas of women with preeclampsia irrespective of the presence or absence of FGR. Discussion: The results of this study suggested that autophagy is active in the placenta of hypertensive disorders even in the absence of FGR. (C) 2014 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0143-4004
関連情報	PMID 25465707
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.placenta.2014.10.009