A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury

Kurokawa, Sei; Katsuki, Shinichi; Fujita, Tomoki; Saitoh, Yusuke; Ohta, Hidetoshi; Nishikawa, Kouji; Sato, Yasushi; Sato, Yasuhiro; Ohira, Koji; Yamada, Masataka; Kato, Mototsugu

A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury

Kurokawa, Sei; Katsuki, Shinichi; Fujita, Tomoki et al.

Journal of gastroenterology, 2014, 49(2), 239-244

Permalink : https://hdl.handle.net/2115/58005

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アクセス権	open access
URI	https://hdl.handle.net/2115/58005
タイトル	A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury
著者	Kurokawa, Sei ; Katsuki, Shinichi ; Fujita, Tomoki ; Saitoh, Yusuke ; Ohta, Hidetoshi ; Nishikawa, Kouji ; Sato, Yasushi ; Sato, Yasuhiro ; Ohira, Koji ; Yamada, Masataka ; Kato, Mototsugu
著者名 Kurokawa, Sei
著者名 Katsuki, Shinichi
著者名 Fujita, Tomoki
著者名 Saitoh, Yusuke
著者名 Ohta, Hidetoshi
著者名 Nishikawa, Kouji
著者名 Sato, Yasushi
著者名 Sato, Yasuhiro
著者名 Ohira, Koji
著者名 Yamada, Masataka
e-Rad_Researcher 60271673 著者名 Kato, Mototsugu
言語	英語
キーワード	NSAID
	Aspirin
	Small intestinal injury
	Capsule endoscopy
	Nutritional parameter
発行日	2014-02
出版者	Springer japan kk
収録物名	Journal of gastroenterology
巻(号)	49(2)
ページ	239-244
抄録	It is not clear what kind of drug is appropriate to heal NSAID-induced enteropathy. Several reports showed the preventive effect of prostaglandin analogue or inducer using healthy subjects who took NSAIDs. However there was no report for healing effect and for patients. The aim of this study was to evaluate the healing effect of rebamipide in patients with NSAIDs-induced enteropathy. In addition, we evaluated for nutritional parameter. This study was conducted as a randomized, double-blinded, placebo-controlled, multicenter trial. Study protocol was approved by each hospital's ethical committees. Patients with LDA and/or NSAID more than 3 months were enrolled. Patients with enteropathy were divided into the placebo and the rebamipide groups. Rebamipide 100 mg three times daily was administered during 4 weeks. Capsule endoscopies were performed at 0 and 4 week. The number of small intestinal ulcer and erosion were evaluated. Total protein was analyzed as nutritional parameter. Sixty one participants were completed this study. Change in number of small intestinal erosion in the rebamipide group was -2.5 +/- A 3.4, and 2.1 +/- A 3.9 in the placebo group (P < 0.0001). Change in number of small intestinal ulcer in the rebamipide group was -0.5 +/- A 1.6, and 0.1 +/- A 0.7 in the placebo group (P = 0.024). Change in serum total protein levels in the rebamipide group was 0.06 +/- A 0.36, and -0.27 +/- A 0.34 in the placebo group (P = 0.0005). Rebamipide has not only the healing effect for NSAIDs-induced enteropathy compared with placebo, but the improvement of nutritional condition. These results showed a tentative therapeutical strategy for chronic NSAIDs users.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0944-1174
NCID	AA10988015
関連情報	PMID 23595613
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00535-013-0805-2