Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA

Watanabe, Hiroaki; Tokiwano, Tetsuo; Oikawa, Hideaki

Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA

Watanabe, Hiroaki; Tokiwano, Tetsuo; Oikawa, Hideaki

Tetrahedron Letters, 2006, 47(9), 1399-1402

Permalink : https://hdl.handle.net/2115/5813

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アクセス権	open access
URI	https://hdl.handle.net/2115/5813
タイトル	Biosynthetic study of FR-900848: unusual observation on polyketide biosynthesis that did not accept acetate as origin of acetyl-CoA
著者	Watanabe, Hiroaki ; Tokiwano, Tetsuo ; Oikawa, Hideaki
著者名 Watanabe, Hiroaki
著者名 Tokiwano, Tetsuo 常盤野, 哲生
e-Rad_Researcher 00185175 著者名 Oikawa, Hideaki 及川, 英秋
言語	英語
キーワード	FR-900848
	Antifungal agent
	Biosynthesis
	Polyketide
	Polycyclopropane
	Aminonucleoside
発行日	2006-02-27
出版者	Elsevier
収録物名	Tetrahedron Letters
巻(号)	47(9)
ページ	1399-1402
抄録	The biosynthetic pathway of a potent antifungal agent, FR-900848, has been examined by administration of several 13C-labeled precursors to Streptoverticillium fervens HP-891. Although none of the 13C-labeled acetate was incorporated into FR-900848, the labeling pattern of FR-900848 derived from d-[U-13C6]glucose revealed that the fatty acid backbone of FR-900848 has been biosynthesized via a polyketide pathway. These unusual results strongly show that the major pathway to provide acetyl-CoA in this microorganism is glycolysis. Feeding experiments with d-[U-13C6]glucose, [1,3-13C2]glycerol, and l-[Me-13C]methionine provided information on the biosynthetic origin of structurally unusual parts (polycyclopropane and aminonucleoside) in this antibiotic.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0040-4039
関連情報	URI http://www.sciencedirect.com/science/journal/00404039
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tetlet.2005.12.091