Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy

Kitai, Hidenori; Sakakibara-Konishi, Jun; Oizumi, Satoshi; Hirohashi, Yoshihiko; Saito, Wataru; Kanda, Atsuhiro; Sato, Noriyuki; Nishimura, Masaharu

Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy

Kitai, Hidenori; Sakakibara-Konishi, Jun; Oizumi, Satoshi et al.

Lung Cancer, 2015, 87(1), 73-76

Permalink : https://hdl.handle.net/2115/58435

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/58435
タイトル	Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy
著者	Kitai, Hidenori ; Sakakibara-Konishi, Jun ; Oizumi, Satoshi ; Hirohashi, Yoshihiko ; Saito, Wataru ; Kanda, Atsuhiro ; Sato, Noriyuki ; Nishimura, Masaharu
著者名 Kitai, Hidenori
e-Rad_Researcher 50374278 著者名 Sakakibara-Konishi, Jun
e-Rad_Researcher 10421968 著者名 Oizumi, Satoshi
e-Rad_Researcher 30516901 著者名 Hirohashi, Yoshihiko
著者名 Saito, Wataru
e-Rad_Researcher 80342707 著者名 Kanda, Atsuhiro
e-Rad_Researcher 50158937 著者名 Sato, Noriyuki
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	Small cell lung cancer
	Cancer associated retinopathy
	Spontaneous regression
	Recoverin
	Cytotoxic T lymphocytes
	Immnologic reaction
発行日	2015-01
出版者	Elsevier Ireland
収録物名	Lung Cancer
巻(号)	87(1)
ページ	73-76
抄録	Spontaneous regression (SR) is defined as the complete or partial disappearance of disease without anticancer treatments. We report a case of SR of small cell lung cancer (SCLC) combined with cancer associated retinopathy (CAR). A 65-year-old woman was admitted to our hospital to examine abnormal shadows of the lung with visual loss. She was diagnosed with SCLC associated with CAR. Subsequent chest X-ray and CT scan showed partial regression of both primary tumor and lymph node metastasis without anticancer treatment. Recoverin antigen was present on the tumor cells and anti-recoverin antibody was observed in the patient's serum. Activation of recoverin-specific antitumor cytotoxic T lymphocyte (CTL) was observed in this patient. SCLC was considered to reduce spontaneously by the activation of recoverin-specific antitumor CTL. To the best of our knowledge, this is the first report of SR in SCLC combined with CAR. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0169-5002
関連情報	PMID 25468200
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.lungcan.2014.10.015