Surgery for recurrent biliary carcinoma : results for 27 recurrent cases

Noji, Takehiro; Tsuchikawa, Takahiro; Mizota, Tomoko; Okamura, Keisuke; Nakamura, Toru; Tamoto, Eiji; Shichinohe, Toshiaki; Hirano, Satoshi

Surgery for recurrent biliary carcinoma : results for 27 recurrent cases

Noji, Takehiro; Tsuchikawa, Takahiro; Mizota, Tomoko et al.

World Journal Of Surgical Oncology, 2015, 13, 82

Permalink : https://hdl.handle.net/2115/58561

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アクセス権	open access
URI	https://hdl.handle.net/2115/58561
タイトル	Surgery for recurrent biliary carcinoma : results for 27 recurrent cases
著者	Noji, Takehiro ; Tsuchikawa, Takahiro ; Mizota, Tomoko ; Okamura, Keisuke ; Nakamura, Toru ; Tamoto, Eiji ; Shichinohe, Toshiaki ; Hirano, Satoshi
著者名 Noji, Takehiro
著者名 Tsuchikawa, Takahiro
著者名 Mizota, Tomoko
著者名 Okamura, Keisuke
著者名 Nakamura, Toru
著者名 Tamoto, Eiji
e-Rad_Researcher 70374353 著者名 Shichinohe, Toshiaki
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
言語	英語
キーワード	Recurrent biliary malignancy
	Extrahepatic cholangiocarcinoma
	Gallbladder carcinoma
	Surgery
	Chemotherapy
	Survival
発行日	2015-02-27
出版者	Biomed Central Ltd
収録物名	World Journal Of Surgical Oncology
巻(号)	13
ページ	82
抄録	Background: Various chemotherapies have been used as best practice to treat recurrent biliary malignancies. Conversely, relatively few surgeries have been described for recurrent extrahepatic biliary carcinoma (RExBC), so whether surgery for RExBC is feasible has remained unclear. This retrospective study was conducted to evaluate the feasibility of surgery for RExBC. Methods: From February 2000 to January 2014, a total of 27 patients, comprising 18 patients with extrahepatic cholangiocarcinoma and 9 patients with gallbladder carcinoma, met our criteria for radical resection of RExBC (resection group). Sites of recurrence consisted of liver metastases (ten patients), local/percutaneous transhepatic cholangio drainage (PTCD) fistula recurrence (eight patients), bile duct recurrence (six patients), and lymph node recurrence (one patient). To evaluate the survival impact of resection, we compared 123 RExBC patients (resection group) with patients who received palliative care (palliative group). Results: Morbidity and mortality rates in the resection group were 6.6% and 0%, respectively. Overall cumulative 5-year survival rates were 23.5% in the resection group and 0% in the palliative group. Median survival time was 21.6 months in the resection group and 9.5 months in the palliative group, showing a significant difference (p < 0.01). No significant differences in cumulative survival were seen between extrahepatic cholangiocarcinoma and gallbladder carcinoma in the resection group. In addition, no significant differences were seen between liver metastases, bile duct recurrence, and local/percutaneous transhepatic biliary drainage (PTBD) fistula recurrence in the resection group. Conclusions: Surgery appears feasible for RExBC and offers longer survival for selected patients.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1477-7819
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s12957-015-0507-8