Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children

Mitsui, Takahiko; Araki, Atsuko; Imai, Ayako; Sato, Sakiko; Miyashita, Chihiro; Ito, Sachiko; Sasaki, Seiko; Kitta, Takeya; Moriya, Kimihiko; Cho, Kazutoshi; Morioka, Keita; Kishi, Reiko; Nonomura, Katsuya

Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children

Mitsui, Takahiko; Araki, Atsuko; Imai, Ayako et al.

Plos one, 2015, 10(3), e0120636

Permalink : https://hdl.handle.net/2115/58951

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アクセス権	open access
URI	https://hdl.handle.net/2115/58951
タイトル	Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children
著者	Mitsui, Takahiko ; Araki, Atsuko ; Imai, Ayako ; Sato, Sakiko ; Miyashita, Chihiro ; Ito, Sachiko ; Sasaki, Seiko ; Kitta, Takeya ; Moriya, Kimihiko ; Cho, Kazutoshi ; Morioka, Keita ; Kishi, Reiko ; Nonomura, Katsuya
e-Rad_Researcher 90421966 著者名 Mitsui, Takahiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
著者名 Imai, Ayako
著者名 Sato, Sakiko
著者名 Miyashita, Chihiro
著者名 Ito, Sachiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 40374441 著者名 Kitta, Takeya
e-Rad_Researcher 20374233 著者名 Moriya, Kimihiko
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
著者名 Morioka, Keita
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
e-Rad_Researcher 60113750 著者名 Nonomura, Katsuya
言語	英語
発行日	2015-03-06
出版者	Public Library Science
収録物名	Plos one
巻(号)	10(3)
ページ	e0120636
抄録	Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged children. Of the 514 children who participated in a prospective cohort study on birth in Sapporo between 2002 and 2005, the following sex hormone levels were measured in 294 stored cord blood samples (135 boys and 159 girls); testosterone (T), estradiol (E), progesterone, LH, FSH, inhibin B, and insulin-like factor 3 (INSL3). A total of 350 children, who were of school age and could be contacted for this survey, were then requested via mail to send black-and-white photocopies of the palms of both the left and right hands. 2D/4D was calculated in 190 children (88 boys and 102 girls) using photocopies and derived from participants with the characteristics of older mothers, a higher annual household income, higher educational level, and fewer smokers among family members. 2D/4D was significantly lower in males than in females (p<0.01). In the 294 stored cord blood samples, T, T/E, LH, FSH, Inhibin B, and INSL3 levels were significantly higher in samples collected from males than those from females. A multivariate regression model revealed that 2D/4D negatively correlated with INSL3 in males and was significantly higher in males with <0.32 ng/mL of INSL3 (p<0.01). No correlations were observed between other hormones and 2D/4D. In conclusion, 2D/4D in school-aged children, which was significantly lower in males than in females, was affected by prenatal Leydig cell function.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0120636