Olfactory neuroblastoma : the long-term outcome and late toxicity of multimodal therapy including radiotherapy based on treatment planning using computed tomography

Mori, Takashi; Onimaru, Rikiya; Onodera, Shunsuke; Tsuchiya, Kazuhiko; Yasuda, Koichi; Hatakeyama, Hiromitsu; Kobayashi, Hiroyuki; Terasaka, Shunsuke; Homma, Akihiro; Shirato, Hiroki

Olfactory neuroblastoma : the long-term outcome and late toxicity of multimodal therapy including radiotherapy based on treatment planning using computed tomography

Mori, Takashi; Onimaru, Rikiya; Onodera, Shunsuke et al.

Radiation oncology, 2015, 10, 88

Permalink : https://hdl.handle.net/2115/59194

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アクセス権	open access
URI	https://hdl.handle.net/2115/59194
タイトル	Olfactory neuroblastoma : the long-term outcome and late toxicity of multimodal therapy including radiotherapy based on treatment planning using computed tomography
著者	Mori, Takashi ; Onimaru, Rikiya ; Onodera, Shunsuke ; Tsuchiya, Kazuhiko ; Yasuda, Koichi ; Hatakeyama, Hiromitsu ; Kobayashi, Hiroyuki ; Terasaka, Shunsuke ; Homma, Akihiro ; Shirato, Hiroki
著者名 Mori, Takashi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
著者名 Onodera, Shunsuke
e-Rad_Researcher 60580892 著者名 Tsuchiya, Kazuhiko
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
著者名 Kobayashi, Hiroyuki
e-Rad_Researcher 10447055 著者名 Terasaka, Shunsuke
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Olfactory neuroblastoma
	Computed tomography
	Three-dimensional conformal radiotherapy
	Late adverse effect
発行日	2015-04-16
出版者	BioMed Central
収録物名	Radiation oncology
巻(号)	10
ページ	88
抄録	Background: Olfactory neuroblastoma (ONB) is a rare tumor originating from olfactory epithelium. Here we retrospectively analyzed the long-term treatment outcomes and toxicity of radiotherapy for ONB patients for whom computed tomography (CT) and three-dimensional treatment planning was conducted to reappraise the role of radiotherapy in the light of recent advanced technology and chemotherapy. Methods: Seventeen patients with ONB treated between July 1992 and June 2013 were included. Three patients were Kadish stage B and 14 were stage C. All patients were treated with radiotherapy with or without surgery or chemotherapy. The radiation dose was distributed from 50 Gy to 66 Gy except for one patient who received 40 Gy preoperatively. Results: The median follow-up time was 95 months (range 8-173 months). The 5-year overall survival (OS) and relapse-free survival (RFS) rates were estimated at 88% and 74%, respectively. Five patients with stage C disease had recurrence with the median time to recurrence of 59 months (range 7-115 months). Late adverse events equal to or above Grade 2 in CTCAE v4.03 were observed in three patients. Conclusion: Multimodal therapy including radiotherapy with precise treatment planning based on CT simulation achieved an excellent local control rate with acceptable toxicity and reasonable overall survival for patients with ONB.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1748-717X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s13014-015-0397-5