Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency

Moriguchi, Rumiko; Kogure, Kentaro; Iwasa, Akitada et al.

Journal of Controlled Release, 2006, 110(3), 605-609

Permalink : https://hdl.handle.net/2115/5922

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アクセス権
open access
URI
https://hdl.handle.net/2115/5922
タイトル
Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency
著者
Moriguchi, Rumiko ; Kogure, Kentaro ; Iwasa, Akitada ; Akita, Hidetaka ; Hideyoshi, Harashima
著者名
Moriguchi, Rumiko
著者名
Kogure, Kentaro
著者名
Iwasa, Akitada
著者名
Akita, Hidetaka
e-Rad_Researcher
00183567
著者名
Hideyoshi, Harashima
原島, 秀吉
言語
英語
キーワード
non-viral gene delivery system
intracellular pharmacokinetics
pharmacodinamics
synergism
発行日
2006-02
出版者
Elsevier B.V
収録物名
Journal of Controlled Release
巻(号)
110(3)
ページ
605-609
記述
http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description
抄録
A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional envelope-type nano device (R8-MEND). We measured the nuclear delivery of pDNA to distinguish the non-linearity in intracellular pharmacokinetics or pharmacodynamics after transfection with R8-MEND at different doses. A remarkable positive non-linearity was found in the pharmacodynamics when the dose was increased. Even dummy pDNA enhanced the efficiency of transcription and/or translation per pDNA in the nucleus, but empty liposomes did not. These results suggest the importance of controlled pharmacodynamics as well as the importance of intracellular pharmacokinetics for the rational design of non-viral gene delivery systems.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0168-3659
関連情報
PMID
16360229
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.jconrel.2005.10.021