Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

Ishihara, Seiichiro; Yasuda, Motoaki; Ishizu, Akihiro et al.

Oncotarget, 2015, 6(7), 4602-4614

Permalink : https://hdl.handle.net/2115/59278

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/59278
タイトル
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
著者
Ishihara, Seiichiro ; Yasuda, Motoaki ; Ishizu, Akihiro ; Ishikawa, Masayori ; Shirato, Hiroki ; Haga, Hisashi
著者名
Ishihara, Seiichiro
著者名
Yasuda, Motoaki
著者名
Ishizu, Akihiro
著者名
Ishikawa, Masayori
著者名
Shirato, Hiroki
e-Rad_Researcher
00292045
著者名
Haga, Hisashi
言語
英語
キーワード
Activating transcription factor 5
radioresistance
cell growth
cell invasion
cancer cells
発行日
2015-03-10
出版者
Impact Journals
収録物名
Oncotarget
巻(号)
6(7)
ページ
4602-4614
抄録
Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not known how cancer cells survive and generate malignant tumors after irradiation. Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation. In the G1-S phase of the cell cycle, cancer cells express high levels of ATF5, which promotes cell cycle progression and thereby increases radioresistance. Furthermore, ATF5 increases malignant phenotypes, such as cell growth and invasiveness, in cancer cells in vitro and in vivo. We have identified a new mechanism for the regeneration of highly malignant tumors after irradiation and shown that ATF5 plays a key role in the process.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 3.0 Unported
PISSN
1949-2553
関連情報
PMID
25682872