Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients

Nagai, Katsura; Makita, Hironi; Suzuki, Masaru; Shimizu, Kaoruko; Konno, Satoshi; Ito, Yoichi M.; Nishimura, Masaharu

Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients

Nagai, Katsura; Makita, Hironi; Suzuki, Masaru et al.

International journal of chronic obstructive pulmonary disease, 2015, 10(1), 745-757

Permalink : https://hdl.handle.net/2115/59284

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アクセス権	open access
URI	https://hdl.handle.net/2115/59284
タイトル	Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients
著者	Nagai, Katsura ; Makita, Hironi ; Suzuki, Masaru ; Shimizu, Kaoruko ; Konno, Satoshi ; Ito, Yoichi M. ; Nishimura, Masaharu
e-Rad_Researcher 40374293 著者名 Nagai, Katsura
e-Rad_Researcher 70533537 著者名 Makita, Hironi
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
e-Rad_Researcher 40399853 著者名 Shimizu, Kaoruko
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	annual change
	forced expiratory volume in 1 second
	SGRQ
	smoking
	exacerbation
発行日	2015-04
出版者	Dove Medical Press
収録物名	International journal of chronic obstructive pulmonary disease
巻(号)	10(1)
ページ	745-757
抄録	Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on Delta FEV1/year. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, Delta FEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement. Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 3.0 Unported
PISSN	1178-2005
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2147/COPD.S77586