On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red

Kimura, Hiroyuki; Kawahara, Koichi; Yamauchi, Yoshiko; Miyaki, Jyunichi

On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red

Kimura, Hiroyuki; Kawahara, Koichi; Yamauchi, Yoshiko et al.

Journal of Electrocardiology, 2005, 38(4), 364-370

Permalink : https://hdl.handle.net/2115/5930

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アクセス権	open access
URI	https://hdl.handle.net/2115/5930
タイトル	On the mechanisms for the conversion of ventricular fibrillation to tachycardia by perfusion with ruthenium red
著者	Kimura, Hiroyuki ; Kawahara, Koichi ; Yamauchi, Yoshiko ; Miyaki, Jyunichi
著者名 Kimura, Hiroyuki
e-Rad_Researcher 20125397 著者名 Kawahara, Koichi 河原, 剛一
e-Rad_Researcher 50230313 著者名 Yamauchi, Yoshiko
著者名 Miyaki, Jyunichi
言語	英語
キーワード	Ventricular fibrillation
	Ventricular tachycardia
	Action potential duration
	Mitochondria
	Ruthenium red
	Restitution curve
発行日	2005-10
出版者	Elsevier Inc.
収録物名	Journal of Electrocardiology
巻(号)	38(4)
ページ	364-370
抄録	We have recently demonstrated that during pacing-induced sustained ventricular fibrillation (VF), perfusion of the heart with either ruthenium red (RR) or Ru 360, blockers of the mitochondrial Ca2+ uniporter, resulted in the reversible conversion of VF to ventricular tachycardia (VT). Here, we aimed at elucidating the electrophysiological mechanisms for the RR-induced conversion of VF to VT. The experiments were performed using Langendorff-perfused isolated rat hearts in which left ventricular pressure and left ventricular intracellular action potential were recorded. Perfusion with either RR or Ru 360 resulted in decreases in the action potential duration (APD), refractory period, and slope of APD restitution curves. These changes were antagonized by cotreatment with S(−)-Bay K8644. In addition, perfusion with verapamil produced the decreases in APD at 90% repolarization, refractory period and slope of APD restitution curves similar to the RR or Ru 360 perfusion. Such electrophysiological changes may be responsible for the reversible conversion of sustained VF to VT caused by perfusion with RR or Ru 360.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0022-0736
関連情報	PMID 16216614
関連情報	URI http://www.sciencedirect.com/science/journal/00220736
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jelectrocard.2005.05.007