Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts

Kawahara, Koichi; Takase, Marei; Yamauchi, Yoshiko; Kimura, Hiroyuki

Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts

Kawahara, Koichi; Takase, Marei; Yamauchi, Yoshiko et al.

Journal of Electrocardiology, 2004, 37(2), 89-100

Permalink : https://hdl.handle.net/2115/5932

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アクセス権	open access
URI	https://hdl.handle.net/2115/5932
タイトル	Spectral and correlation analyses of the verapamil-induced conversion of ventricular fibrillation to tachycardia in isolated rat hearts
著者	Kawahara, Koichi ; Takase, Marei ; Yamauchi, Yoshiko ; Kimura, Hiroyuki
e-Rad_Researcher 20125397 著者名 Kawahara, Koichi 河原, 剛一
著者名 Takase, Marei
e-Rad_Researcher 50230313 著者名 Yamauchi, Yoshiko
著者名 Kimura, Hiroyuki
言語	英語
キーワード	Ventricular fibrillation
	ventricular tachycardia
	VT/VF transition
	calcium channels
	verapamil
発行日	2004-04
出版者	Elsevier Inc.
収録物名	Journal of Electrocardiology
巻(号)	37(2)
ページ	89-100
抄録	Ventricular tachycardia (VT) is considered to be the most common precursor of ventricular fibrillation (VF). However, the mechanisms underlying the transition from VT to VF remain unclear. Here, we investigated whether and how perfusion of the heart with verapamil, a blocker of L-type calcium channels, changed the macro-dynamics of the heart between VT and VF. The experiments were performed with Langendorff perfused isolated rat hearts, in which left ventricular pressure and left ventricular cardiomyogram were measured. Sustained VT or VF was induced by burst pacing of the left ventricular muscles. During sustained VF, verapamil perfusion resulted in the conversion of VF to VT. A cross-correlation analysis between left ventricular cardiomyogram and left ventricular pressure revealed that the correlation coefficient was small during VF, but became larger during VT. This study showed that inactivation of L-type Ca2+ channels occurred during verapamil-induced conversion of pacing-induced sustained VF to VT, and characterized the changes in macro-dynamics of the heart associated with the transition.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	http://www.elsevier.com/wps/find/journaldescription.cws_home/623308/description
PISSN	0022-0736
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jelectrocard.2004.01.006