Nitric Oxide Produced During Ischemia Is Toxic but Crucial to Preconditioning-Induced Ischemic Tolerance of Neurons in Culture

Kawahara, Koichi; Yanoma, Junji; Tanaka, Motoki et al.

Neurochemical Research, 2004, 29(4), 797-804

Permalink : https://hdl.handle.net/2115/5933

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アクセス権
open access
URI
https://hdl.handle.net/2115/5933
タイトル
Nitric Oxide Produced During Ischemia Is Toxic but Crucial to Preconditioning-Induced Ischemic Tolerance of Neurons in Culture
著者
Kawahara, Koichi ; Yanoma, Junji ; Tanaka, Motoki ; Nakajima, Takayuki ; Kosugi, Tatsuro
e-Rad_Researcher
20125397
著者名
Kawahara, Koichi
河原, 剛一
著者名
Yanoma, Junji
著者名
Tanaka, Motoki
著者名
Nakajima, Takayuki
著者名
Kosugi, Tatsuro
言語
英語
キーワード
Ischemia
preconditioning
nitric oxide
neurotoxicity
cortical culture
発行日
2004-04
出版者
Springer Netherlands
収録物名
Neurochemical Research
巻(号)
29(4)
ページ
797-804
抄録
The present study investigated the roles of nitric oxide (NO) in preconditioning (PC)-induced neuronal ischemic tolerance in cortical cultures. Ischemia in vitro was simulated by subjecting cultures to both oxygen and glucose deprivation (OGD). A sublethal OGD (PC) significantly increased the survival rate of neurons when cultures were exposed to a lethal OGD 24 h later. Both the inhibition of nitric oxide synthase (NOS) and scavenging of NO during PC significantly attenuated the PC-induced neuronal tolerance. In addition, exposure to an NO donor emulated the PC. In contrast, the inhibition of NOS and the scavenging of NO during lethal OGD tended to increase the survival rate of neurons. This study suggested that NO produced during ischemia was fundamentally toxic, but critical to the development of PC-induced neuronal tolerance.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com. Former publisher: Kluwer Academic Publishers.
PISSN
0364-3190
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1023/B:NERE.0000018853.30131.4d