Possible involvement of nitric oxide in the modulation of photolytic flash-induced intercellular calcium waves in cultured astrocytes

Kawahara, Koichi; Iwabuchi, Sadahiro

Neuroscience Research Communications, 2003, 32(3), 189-196

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アクセス権
open access
URI
https://hdl.handle.net/2115/5936
タイトル
Possible involvement of nitric oxide in the modulation of photolytic flash-induced intercellular calcium waves in cultured astrocytes
著者
e-Rad_Researcher
20125397
著者名
Kawahara, Koichi
河原, 剛一
著者名
Iwabuchi, Sadahiro
言語
英語
キーワード
calcium waves
caged ionophore
photolysis
astrocyte
nitric oxide
発行日
2003
出版者
Wiley-Liss, Inc.
収録物名
Neuroscience Research Communications
巻(号)
32(3)
ページ
189-196
抄録
Waves of elevated intracellular free calcium that propagate between neighboring astrocytes are important for the intercellular communication between astrocytes as well as between neurons and astrocytes. In this study, intercellular calcium waves were evoked by focal photolysis of a caged calcium inophore in cultured astrocytes. The focal photolysis of the caged compound resulted in an increase of intracellular calcium in the flashed cells, and this increase then propagated to neighboring astrocytes. The evoked calcium increase was inhibited by incubating cells with an inhibitor of nitric oxide synthase as well as with a scavenger of nitric oxide (NO). In addition, treatment of cultures with an NO donor resulted in the marked enhancement of the photolytic flash-induced calcium rise in astrocytes. This enhancement was reversed by treatment with inhibitors of soluble guanylyl cyclase as well as of protein kinase G.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Copyright © 2003 John Wiley & Sons, Inc., Neuroscience Research Communications, vol. 32-3, p. 189-196
PISSN
0893-6609
関連情報
URI
http://www.interscience.wiley.com/
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1002/nrc.10073