Acute Zonal Occult Outer Retinopathy in Japanese Patients : Clinical Features, Visual Function, and Factors Affecting Visual Function

Saito, Saho; Saito, Wataru; Saito, Michiyuki; Hashimoto, Yuki; Mori, Shohei; Noda, Kousuke; Namba, Kenichi; Ishida, Susumu

Acute Zonal Occult Outer Retinopathy in Japanese Patients : Clinical Features, Visual Function, and Factors Affecting Visual Function

Saito, Saho; Saito, Wataru; Saito, Michiyuki et al.

PLOS ONE, 2015, 10(4), e0125133

Permalink : https://hdl.handle.net/2115/59432

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アクセス権	open access
URI	https://hdl.handle.net/2115/59432
タイトル	Acute Zonal Occult Outer Retinopathy in Japanese Patients : Clinical Features, Visual Function, and Factors Affecting Visual Function
著者	Saito, Saho ; Saito, Wataru ; Saito, Michiyuki ; Hashimoto, Yuki ; Mori, Shohei ; Noda, Kousuke ; Namba, Kenichi ; Ishida, Susumu
著者名 Saito, Saho
著者名 Saito, Wataru
著者名 Saito, Michiyuki
著者名 Hashimoto, Yuki
著者名 Mori, Shohei
e-Rad_Researcher 90296666 著者名 Noda, Kousuke
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
言語	英語
発行日	2015-04-28
出版者	PLOS
収録物名	PLOS ONE
巻(号)	10(4)
ページ	e0125133
抄録	Purpose To evaluate the clinical features and investigate their relationship with visual function in Japanese patients with acute zonal occult outer retinopathy (AZOOR). Methods Fifty-two eyes of 38 Japanese AZOOR patients (31 female and 7 male patients; mean age at first visit, 35.0 years; median follow-up duration, 31 months) were retrospectively collected: 31 untreated eyes with good visual acuity and 21 systemic corticosteroid-treated eyes with progressive visual acuity loss. Variables affecting the logMAR values of best-corrected visual acuity (BCVA) and the mean deviation (MD) on Humphrey perimetry at initial and final visits were examined using multiple stepwise linear regression analysis. Results In untreated eyes, the mean MD at the final visit was significantly higher than that at the initial visit (P = 0.00002). In corticosteroid-treated eyes, the logMAR BCVA and MD at the final visit were significantly better than the initial values (P = 0.007 and P = 0.02, respectively). The final logMAR BCVA was 0.0 or less in 85% of patients. Variables affecting initial visual function were moderate anterior vitreous cells, myopia severity, and a-wave amplitudes on electroretinography; factors affecting final visual function were the initial MD values, female sex, moderate anterior vitreous cells, and retinal atrophy. Conclusions Our data indicated that visual functions in enrolled patients significantly improved spontaneously or after systemic corticosteroids therapy, suggesting that Japanese patients with AZOOR have good visual outcomes during the follow-up period of this study. Furthermore, initial visual field defects, gender, anterior vitreous cells, and retinal atrophy affected final visual functions in these patients.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0125133