Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors

Sato, Shoki; Tsuchikawa, Takahiro; Nakamura, Toru; Sato, Nagato; Tamoto, Eiji; Okamura, Keisuke; Shichinohe, Toshiaki; Hirano, Satoshi

Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors

Sato, Shoki; Tsuchikawa, Takahiro; Nakamura, Toru et al.

Oncology reports, 2014, 32(6), 2753-2759

Permalink : https://hdl.handle.net/2115/59434

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アクセス権	open access
URI	https://hdl.handle.net/2115/59434
タイトル	Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors
著者	Sato, Shoki ; Tsuchikawa, Takahiro ; Nakamura, Toru ; Sato, Nagato ; Tamoto, Eiji ; Okamura, Keisuke ; Shichinohe, Toshiaki ; Hirano, Satoshi
著者名 Sato, Shoki
著者名 Tsuchikawa, Takahiro
著者名 Nakamura, Toru
著者名 Sato, Nagato
著者名 Tamoto, Eiji
著者名 Okamura, Keisuke
e-Rad_Researcher 70374353 著者名 Shichinohe, Toshiaki
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
言語	英語
キーワード	pancreatic neuroendocrine tumor
	postoperative hepatic recurrence
	tumor-infiltrating lymphocytes
	ATRX/DAXX
	p-mTOR
発行日	2014-12
出版者	Spandidos Publications
収録物名	Oncology reports
巻(号)	32(6)
ページ	2753-2759
抄録	The disease frequency of pancreatic neuroendocrine tumors (PNETs) has been growing, and postoperative hepatic recurrence (PHR) is one of the factors affecting patient prognosis. The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PHR using immunohistochemical analysis for tumor-infiltrating lymphocytes (TILs: CD3, CD8 and CD45RO), human leukocyte antigen (HLA) class I, alpha-thalassemia/mental retardation X-linked (ATRX), death domain-associated protein (DAXX), mammalian target of rapamycin (mTOR) and phospho-mTOR (p-mTOR). Correlations were analyzed between TILs and the biomarkers, clinicopathological features and prognosis. Sixteen patients with PNETs who underwent radical surgery at our hospital were reviewed. We analyzed the correlation between PHR and immunohistochemical characteristics, and also between disease-free survival (DFS) or overall survival (OS) and the immunohistochemical characteristics. We found that PHR was associated with the expression patterns of DAXX and p-mTOR. No association was found between PHR and patient background, TILs or other biomarkers. DFS was found to be associated with ATRX, DAXX and p-mTOR. OS was associated only with p-mTOR. In conclusion, ATRX, DAXX and p-mTOR are useful molecular biomarkers for predicting PHR in patients who undergo radical surgery for PNETs. Use of these biomarkers will enable earlier decisions on which patients may benefit from adjuvant therapy.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1021-335X
関連情報	PMID 25310565
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3892/or.2014.3530