MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

Takahashi, Hidehisa; Takigawa, Ichigaku; Watanabe, Masashi; Anwar, Delnur; Shibata, Mio; Tomomori-Sato, Chieri; Sato, Shigeo; Ranjan, Amol; Seidel, Chris W.; Tsukiyama, Tadasuke; Mizushima, Wataru; Hayashi, Masayasu; Ohkawa, Yasuyuki; Conaway, Joan W.; Conaway, Ronald C.; Hatakeyama, Shigetsugu

MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex

Takahashi, Hidehisa; Takigawa, Ichigaku; Watanabe, Masashi et al.

Nature Communications, 2015, 6, 5941

Permalink : https://hdl.handle.net/2115/59508

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アクセス権	open access
URI	https://hdl.handle.net/2115/59508
タイトル	MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex
著者	Takahashi, Hidehisa ; Takigawa, Ichigaku ; Watanabe, Masashi ; Anwar, Delnur ; Shibata, Mio ; Tomomori-Sato, Chieri ; Sato, Shigeo ; Ranjan, Amol ; Seidel, Chris W. ; Tsukiyama, Tadasuke ; Mizushima, Wataru ; Hayashi, Masayasu ; Ohkawa, Yasuyuki ; Conaway, Joan W. ; Conaway, Ronald C. ; Hatakeyama, Shigetsugu
著者名 Takahashi, Hidehisa
e-Rad_Researcher 10374597 著者名 Takigawa, Ichigaku
著者名 Watanabe, Masashi
著者名 Anwar, Delnur
著者名 Shibata, Mio
著者名 Tomomori-Sato, Chieri
著者名 Sato, Shigeo
著者名 Ranjan, Amol
著者名 Seidel, Chris W.
e-Rad_Researcher 20399819 著者名 Tsukiyama, Tadasuke
著者名 Mizushima, Wataru
著者名 Hayashi, Masayasu
e-Rad_Researcher 80448430 著者名 Ohkawa, Yasuyuki
著者名 Conaway, Joan W.
著者名 Conaway, Ronald C.
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
発行日	2015-01
出版者	Nature Publishing Group
収録物名	Nature Communications
巻(号)	6
ページ	5941
抄録	Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes. Here we show that the human Mediator subunit MED26 plays a role in the recruitment of LEC to a subset of snRNA genes through direct interaction of EAF and the N-terminal domain (NTD) of MED26. Loss of MED26 in cells decreases the occupancy of LEC at a subset of snRNA genes and results in a reduction in their transcription. Our results suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	2041-1723
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/ncomms6941