Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with O-15-H2O PET

Kikuchi, Yasuka; Oyama-Manabe, Noriko; Naya, Masanao; Manabe, Osamu; Tomiyama, Yuuki; Sasaki, Tsukasa; Katoh, Chietsugu; Kudo, Kohsuke; Tamaki, Nagara; Shirato, Hiroki

Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with O-15-H2O PET

Kikuchi, Yasuka; Oyama-Manabe, Noriko; Naya, Masanao et al.

European Radiology, 2014, 24(7), 1547-1556

Permalink : https://hdl.handle.net/2115/59526

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アクセス権	open access
URI	https://hdl.handle.net/2115/59526
タイトル	Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with O-15-H2O PET
著者	Kikuchi, Yasuka ; Oyama-Manabe, Noriko ; Naya, Masanao ; Manabe, Osamu ; Tomiyama, Yuuki ; Sasaki, Tsukasa ; Katoh, Chietsugu ; Kudo, Kohsuke ; Tamaki, Nagara ; Shirato, Hiroki
著者名 Kikuchi, Yasuka
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 20455637 著者名 Naya, Masanao
著者名 Manabe, Osamu
著者名 Tomiyama, Yuuki
著者名 Sasaki, Tsukasa
e-Rad_Researcher 10292012 著者名 Katoh, Chietsugu
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	MDCT
	Cardiac
	Perfusion
	Myocardium blood flow
	Coronary flow reserve
発行日	2014-07
出版者	Springer
収録物名	European Radiology
巻(号)	24(7)
ページ	1547-1556
抄録	This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against O-15-H2O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients. Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (n = 7). Correlation between MBF of MDCT and PET was strong (r = 0.95, P < 0.0001). CFR showed good correlation between dynamic CTP and PET (r = 0.67, P = 0.0126). CFRCT in the CAD group (2.3 +/- 0.8) was significantly lower than that in the validation group (5.2 +/- 1.8) (P = 0.0011). We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP. aEuro cent MBF and CFR can be calculated using dynamic CTP with 320-row MDCT. aEuro cent MBF and CFR showed good correlation between dynamic CTP and PET. aEuro cent Lower CFR was well demonstrated in CAD patients by dynamic CTP.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0938-7994
関連情報	PMID 24744200
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00330-014-3164-3