Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells

Sun, Yongkun; Liu, Chuang; Liu, Yutong; Hosokawa, Toshiyuki; Saito, Takeshi; Kurasaki, Masaaki

Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells

Sun, Yongkun; Liu, Chuang; Liu, Yutong et al.

Journal of Environmental Science and Health, Part A : Toxic/Hazardous Substances & Environmental Engineering, 2014, 49(9), 1023-1028

Permalink : https://hdl.handle.net/2115/59555

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アクセス権	open access
URI	https://hdl.handle.net/2115/59555
タイトル	Changes in the expression of epigenetic factors during copper-induced apoptosis in PC12 cells
著者	Sun, Yongkun ; Liu, Chuang ; Liu, Yutong ; Hosokawa, Toshiyuki ; Saito, Takeshi ; Kurasaki, Masaaki
著者名 Sun, Yongkun
著者名 Liu, Chuang
著者名 Liu, Yutong
e-Rad_Researcher 00157025 著者名 Hosokawa, Toshiyuki
e-Rad_Researcher 40153811 著者名 Saito, Takeshi
e-Rad_Researcher 80161727 著者名 Kurasaki, Masaaki
言語	英語
キーワード	epigenetic
	Sir2
	DNA methylation
	Copper
	oxidative stress
発行日	2014-07-29
出版者	Taylor & Francis
収録物名	Journal of Environmental Science and Health, Part A : Toxic/Hazardous Substances & Environmental Engineering
巻(号)	49(9)
ページ	1023-1028
抄録	Despite extensive research on copper toxicity the mechanisms involved are not fully characterized. There have been many recent reports concerning the relationship between epigenetic factors and cell metabolism, but the effects of copper exposure on epigenetic factors have not been investigated. In this study, an in vitro culture system was employed to study the influence of copper on apoptosis and epigenetic factors in PC12 cells. When PC12 cells were exposed to copper, DNA damage was observed as DNA fragmentation. In addition, cytosolic cytochrome c levels were increased by copper treatment. These results suggested that copper induced apoptosis via an oxidative stress pathway. This was consistent with the observation that copper-induced apoptosis was enhanced by further oxidative stress induced by exposing cells to H2O2. In addition, the epigenetic factors were significantly increased in apoptotic cells following exposure to copper and oxidative stress.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is an Author's Accepted Manuscript of an article published in Journal of Environmental Science and Health, Part A, Toxic/hazardous substances & environmental engineering, Vol. 49, Iss. 9, 2014, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/10934529.2014.894847.
PISSN	1093-4529
NCID	AA11205598
関連情報	PMID 24798901
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/10934529.2014.894847