DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

Oshiumi, Hiroyuki; Miyashita, Moeko; Okamoto, Masaaki; Morioka, Yuka; Okabe, Masaru; Matsumoto, Misako; Seya, Tsukasa

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

Oshiumi, Hiroyuki; Miyashita, Moeko; Okamoto, Masaaki et al.

Cell reports, 2015, 11(8), 1193-1207

Permalink : https://hdl.handle.net/2115/59596

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アクセス権	open access
URI	https://hdl.handle.net/2115/59596
タイトル	DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
著者	Oshiumi, Hiroyuki ; Miyashita, Moeko ; Okamoto, Masaaki ; Morioka, Yuka ; Okabe, Masaru ; Matsumoto, Misako ; Seya, Tsukasa
e-Rad_Researcher 50379103 著者名 Oshiumi, Hiroyuki
著者名 Miyashita, Moeko
著者名 Okamoto, Masaaki
e-Rad_Researcher 00360264 著者名 Morioka, Yuka
e-Rad_Researcher 30089875 著者名 Okabe, Masaru
e-Rad_Researcher 30332456 著者名 Matsumoto, Misako
e-Rad_Researcher 10301805 著者名 Seya, Tsukasa
言語	英語
発行日	2015-05-26
出版者	Cell Press
収録物名	Cell reports
巻(号)	11(8)
ページ	1193-1207
抄録	RIG-I-mediated type I interferon (IFN) production and nuclease-mediated viral RNA degradation are essential for antiviral innate immune responses. DDX60 is an IFN-inducible cytoplasmic helicase. Here, we report that DDX60 is a sentinel for both RIG-I activation and viral RNA degradation. We show that DDX60 is an upstream factor of RIG-I that activates RIG-I signaling in a ligand-specific manner. DDX60 knockout attenuates RIG-I signaling and significantly reduces virus-induced type I IFN production in vivo. In addition, we show that DDX60 is involved in RIG-I-independent viral RNA degradation. DDX60 and RIG-I adaptor MAVS double-knockout mice reveal a role for DDX60-dependent RNA degradation in antiviral responses. Several viruses induced DDX60 phosphorylation via epidermal growth factor receptor (EGFR), leading to attenuation of the DDX60 antiviral activities. Our results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	2211-1247
関連情報	PMID 25981042
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.celrep.2015.04.047