Functional Significance of the Preconditioning-induced Down-regulation of Glutamate Transporter GLT-1 in Neuron/astrocyte Co-cultures

Kosugi, Tatsuro; Kawahara, Koichi; Yamada, Takeshi et al.

Neurochemical Research, 2005, 30(9), 1109-1116

Permalink : https://hdl.handle.net/2115/5971

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アクセス権
open access
URI
https://hdl.handle.net/2115/5971
タイトル
Functional Significance of the Preconditioning-induced Down-regulation of Glutamate Transporter GLT-1 in Neuron/astrocyte Co-cultures
著者
Kosugi, Tatsuro ; Kawahara, Koichi ; Yamada, Takeshi ; Nakajima, Takayuki ; Tanaka, Motoki
著者名
Kosugi, Tatsuro
e-Rad_Researcher
20125397
著者名
Kawahara, Koichi
河原, 剛一
著者名
Yamada, Takeshi
著者名
Nakajima, Takayuki
著者名
Tanaka, Motoki
言語
英語
キーワード
GLT-1
ischemic tolerance
neuron-derived factor
preconditioning
発行日
2005-09
出版者
Springer Netherlands
収録物名
Neurochemical Research
巻(号)
30(9)
ページ
1109-1116
抄録
In the brain, prior sublethal ischemia (preconditioning, PC) is known to produce tolerance of neurons to subsequent lethal ischemia. This study aims at elucidating what alterations were induced in neurons and/or astrocytes by PC treatment. The rise in the extracellular concentration of glutamate during ischemia was markedly suppressed by the prior PC treatment. Immunocytochemical and Western blot analyses demonstrated that the expression of the astrocytic glutamate transporter GLT-1 was transiently down-regulated after the PC insult. The PC insult possibly suppressed the neuron-derived factors up-regulating GLT-1. Here we show that PC-induced down-regulation of GLT-1 is crucial for the increased neuronal resistance to subsequent severe ischemic insult.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The original publication is available at www.springerlink.com
PISSN
0364-3190
関連情報
PMID
16292503
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s11064-005-8219-z