Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva

Oikawa, Junko; Ukawa, Shigekazu; Ohira, Hideki; Kawamura, Takashi; Wakai, Kenji; Ando, Masahiko; Hata, Akira; Tamakoshi, Akiko

Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva

Oikawa, Junko; Ukawa, Shigekazu; Ohira, Hideki et al.

Journal of epidemiology, 2015, 25(7), 470-474

Permalink : https://hdl.handle.net/2115/59746

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アクセス権	open access
URI	https://hdl.handle.net/2115/59746
タイトル	Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva
著者	Oikawa, Junko ; Ukawa, Shigekazu ; Ohira, Hideki ; Kawamura, Takashi ; Wakai, Kenji ; Ando, Masahiko ; Hata, Akira ; Tamakoshi, Akiko
著者名 Oikawa, Junko
e-Rad_Researcher 40706751 著者名 Ukawa, Shigekazu
e-Rad_Researcher 90221837 著者名 Ohira, Hideki
e-Rad_Researcher 10252230 著者名 Kawamura, Takashi
著者名 Wakai, Kenji
著者名 Ando, Masahiko
e-Rad_Researcher 00244541 著者名 Hata, Akira
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	diabetes mellitus
	secretory immunoglobulin A
	saliva
発行日	2015-07
出版者	日本疫学会
出版者	Japan Epidemiological Association
収録物名	Journal of epidemiology
巻(号)	25(7)
ページ	470-474
抄録	Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people. Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status. Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 mu g/min vs 15.0 mu g/min, P = 0.03), even after elimination of the effects of possible confounders. Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	0917-5040
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2188/jea.JE20140088