Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks

Matsunami, Shohei; Ogura, Yukiko; Amita, Hidetoshi; Izumi, Takeshi; Yoshioka, Mitsuhiro; Matsushima, Toshiya

Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks

Matsunami, Shohei; Ogura, Yukiko; Amita, Hidetoshi et al.

Behavioural Brain Research, 2012, 233(2), 577-586

Permalink : https://hdl.handle.net/2115/59799

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アクセス権	open access
URI	https://hdl.handle.net/2115/59799
タイトル	Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks
著者	Matsunami, Shohei ; Ogura, Yukiko ; Amita, Hidetoshi ; Izumi, Takeshi ; Yoshioka, Mitsuhiro ; Matsushima, Toshiya
著者名 Matsunami, Shohei
著者名 Ogura, Yukiko
著者名 Amita, Hidetoshi
e-Rad_Researcher 60312360 著者名 Izumi, Takeshi
e-Rad_Researcher 40182729 著者名 Yoshioka, Mitsuhiro
e-Rad_Researcher 40190459 著者名 Matsushima, Toshiya 松島, 俊也
言語	英語
キーワード	Serotonin
	Dopamine
	Optimal foraging behaviour
	Impulsiveness
	Effort
	Medial striatum
	Nucleus accumbens
	Decision making
発行日	2012-08-01
出版者	Elsevier
収録物名	Behavioural Brain Research
巻(号)	233(2)
ページ	577-586
抄録	Behavioural effects of fluvoxamine (FLV, selective serotonin reuptake inhibitor) were examined in 1–2 week old domestic chicks. Chicks were tested in an I-shaped maze equipped with a feeder (ON feeder) that served 1 or 2 grains of millet at gradually increasing intervals, so that a depleting food patch was mimicked. By leaving the feeder, the food delivery program was reset, and chicks gained food at short intervals only after a travel to a dummy feeder (OFF feeder) placed on the opposite side of the maze. Chicks quickly learned to actively shuttle between the ON and the OFF feeders. FLV (intra-peritoneal injection, 20 mg/kg BW) acutely caused chicks to stay longer at the gradually depleting ON feeder. Inter-temporal choices were also tested, whereby two coloured beads were simultaneously presented, each associated with a small/short-delay reward or a large/long-delay alternative. FLV suppressed the choice of the short-delay option. It is suggested that an enhanced level of serotonin (5-HT) makes chicks more tolerant of the delayed food item in both behavioural paradigms. Furthermore, the decision to leave a depleting patch cannot be equated to choosing the long-delay option of the choice paradigm. Furthermore, FLV suppressed work efforts (velocity and running distance) in uncued shuttle and number of distress calls. In vivo microdialysis experiments revealed that FLV enhanced the extracellular concentration of 5-HT as well as dopamine (DA) locally in the medial striatum/nucleus accumbens. Underlying neuromodulatory mechanisms of behavioural control are examined in relation to locomotion, behavioural tolerance and interval timing.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0166-4328
EISSN	1872-7549
関連情報	PMID 22683919
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbr.2012.05.045