open access

https://hdl.handle.net/2115/59806

α-Amylase Inhibitory Triterpene fromAbrus precatoriusLeaves

英語

triterpene ketone

2014-08

American Chemical Society

Journal of Agricultural and Food Chemistry

62(33)

8411-8414

In the screening experiments for porcine pancreatic α-amylase inhibitors in 18 plants obtained from Indonesia, a potent inhibitory activity was detected in the extract of leaves of Abrus precatorius. The enzyme assay-guided fractionation of the extract led to the isolation of a triterpene ketone, lupenone (1), as a potent α-amylase inhibitor, together with 24- methylenecycloartenone (2) and luteolin (3). The mode of inhibition of compound 1 against porcine pancreatic α -amylase was a mixed inhibition. This is the first report that describes the potent α -amylase inhibitory activity of the low-polar triterpene ketone similar to compound 1. A comparison of the activities of the isolate and related compounds indicated the importance of C-3 ketone and the lupane skeleton in the α -amylase inhibitory activity.

学術雑誌論文

Accepted Manuscript

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/pdf/10.1021/jf502667z, see http://pubs.acs.org/page/policy/articlesonrequest/index.html.

0021-8561

1520-5118