Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity

Fukae, Jun; Isobe, Masato; Kitano, Akemi; Henmi, Mihoko; Sakamoto, Fumihiko; Narita, Akihiro; Ito, Takeya; Mitsuzaki, Akio; Shimizu, Masato; Tanimura, Kazuhide; Matsuhashi, Megumi; Kamishima, Tamotsu; Atsumi, Tatsuya; Koike, Takao

Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity

Fukae, Jun; Isobe, Masato; Kitano, Akemi et al.

Rheumatology, 2014, 53(9), 1608-1612

Permalink : https://hdl.handle.net/2115/59811

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アクセス権	open access
URI	https://hdl.handle.net/2115/59811
タイトル	Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity
著者	Fukae, Jun ; Isobe, Masato ; Kitano, Akemi ; Henmi, Mihoko ; Sakamoto, Fumihiko ; Narita, Akihiro ; Ito, Takeya ; Mitsuzaki, Akio ; Shimizu, Masato ; Tanimura, Kazuhide ; Matsuhashi, Megumi ; Kamishima, Tamotsu ; Atsumi, Tatsuya ; Koike, Takao
著者名 Fukae, Jun
著者名 Isobe, Masato
著者名 Kitano, Akemi
著者名 Henmi, Mihoko
著者名 Sakamoto, Fumihiko
著者名 Narita, Akihiro
著者名 Ito, Takeya
著者名 Mitsuzaki, Akio
著者名 Shimizu, Masato
著者名 Tanimura, Kazuhide
著者名 Matsuhashi, Megumi
e-Rad_Researcher 10399868 著者名 Kamishima, Tamotsu
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
e-Rad_Researcher 80146795 著者名 Koike, Takao
言語	英語
キーワード	rheumatoid arthritis
	ultrasonography
	power Doppler
	clinical remission
	treat to target
発行日	2014-09
出版者	Oxford University Press
収録物名	Rheumatology
巻(号)	53(9)
ページ	1608-1612
抄録	Objective. In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA). Methods. RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks). Results. Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period. Conclusion. Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record "Jun Fukae, Masato Isobe, Akemi Kitano, et al. Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity. Rheumatology (Oxford), September 1, 2014 vol. 53 no. 9, 1608-1612" is available online at: http://dx.doi.org/10.1093/rheumatology/keu154
PISSN	1462-0324
関連情報	PMID 24706991
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/rheumatology/keu154