Association of Body Mass Index and Mortality in Japanese Diabetic Men and Women Based on Self-Reports : The Japan Collaborative Cohort (JACC) Study

Kubota, Yasuhiko; Iso, Hiroyasu; Tamakoshi, Akiko

Journal of epidemiology, 2015, 25(8), 553-558

Permalink : https://hdl.handle.net/2115/59821

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アクセス権
open access
URI
https://hdl.handle.net/2115/59821
タイトル
Association of Body Mass Index and Mortality in Japanese Diabetic Men and Women Based on Self-Reports : The Japan Collaborative Cohort (JACC) Study
著者
Kubota, Yasuhiko ; Iso, Hiroyasu ; Tamakoshi, Akiko
著者名
Kubota, Yasuhiko
e-Rad_Researcher
50223053
著者名
Iso, Hiroyasu
e-Rad_Researcher
90236737
著者名
Tamakoshi, Akiko
言語
英語
キーワード
diabetes
body mass index
mortality
infection
obesity paradox
発行日
2015-08
出版者
日本疫学会
Japan Epidemiological Association
収録物名
Journal of epidemiology
巻(号)
25(8)
ページ
553-558
抄録
Background: The association between body mass index (BMI) and mortality among Asian diabetic people, especially with respect to the obesity paradox (ie, higher BMI is associated with lower mortality risk), remains unresolved. Methods: We followed a cohort of 3851 self-reported Japanese diabetics (2115 men and 1736 women) in the Japan Collaborative Cohort Study from 1988-1990 through 2009. Individuals were aged 40 to 79 years and free from a history of cardiovascular disease, cancer, renal disease, or tuberculosis. BMI was grouped into the following four categories: <20.0, 20.0-22.9, 23.0-24.9, and >= 25.0 kg/m(2). Results: During 54 707 person-years of follow-up, 1457 deaths from all causes, 445 from cardiovascular disease, 421 from cancer, 43 from renal disease, and 148 from infectious disease were documented. Mortality from all causes, cardiovascular disease, cancer, and renal disease showed L-shaped associations with BMI. Compared to diabetics with BMI of 20.0-22.9 kg/m(2), those with BMIs of 23.0-24.9 kg/m(2) and >= 25.0 kg/m(2) had lower risks of mortality from infectious disease (ie, obesity paradox). The multivariable HRs for mortality from infectious disease were 0.50 (95% confidence interval, 0.31-0.81) and 0.51 (95% confidence interval, 0.32-0.82) among participants with BMIs of 23.0-24.9 kg/m(2) and >= 25.0 kg/m(2), respectively. Similar results were observed after stratification by smoking status and age and exclusion of early deaths. Conclusions: We observed L-shaped associations between BMI and mortality from all causes, cardiovascular disease, cancer, and renal disease, while the association between BMI and mortality from infectious disease manifested the obesity paradox.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 3.0 Unported
PISSN
0917-5040
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.2188/jea.JE20150011