Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs

MIYAJI, Hirofumi; SUGAYA, Tsutomu; IBE, Keisuke; ISHIZUKA, Ryousuke; TOKUNAGA, Keisuke; KAWANAMI, Masamitsu

Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs

MIYAJI, Hirofumi; SUGAYA, Tsutomu; IBE, Keisuke et al.

Journal of Oral Tissue Engineering, 2011, 8(3), 173-180

Permalink : https://hdl.handle.net/2115/59873

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アクセス権	open access
URI	https://hdl.handle.net/2115/59873
タイトル	Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs
著者	MIYAJI, Hirofumi ; SUGAYA, Tsutomu ; IBE, Keisuke ; ISHIZUKA, Ryousuke ; TOKUNAGA, Keisuke ; KAWANAMI, Masamitsu
e-Rad_Researcher 50372256 著者名 MIYAJI, Hirofumi 著者別名 MIYAJI, Hirofumi
e-Rad_Researcher 10211301 著者名 SUGAYA, Tsutomu 著者別名 SUGAYA, Tsutomu
著者名 IBE, Keisuke 著者別名 IBE, Keisuke
著者名 ISHIZUKA, Ryousuke 著者別名 ISHIZUKA, Ryousuke
著者名 TOKUNAGA, Keisuke 著者別名 TOKUNAGA, Keisuke
e-Rad_Researcher 10133761 著者名 KAWANAMI, Masamitsu 著者別名 KAWANAMI, Masamitsu
言語	英語
キーワード	bone morphogenetic protein-2
	root dentin surface conditioning
	periodontal wound healing
	dog
発行日	2011-03-30
出版者	Japanese Association of Regenerative Dentistry
出版者	日本再生歯科医学会
収録物名	Journal of Oral Tissue Engineering
巻(号)	8(3)
ページ	173-180
抄録	Bone morphogenetic protein-2 (BMP-2) may play a major role in osteoinduction and osteoclast differentiation. The influence of BMP-2 conditioning in graded doses to root dentin surface on periodontal wound healing was examined.Twenty-four periodontal defects were surgically created on the buccal roots of four beagle dogs. The denuded root dentin surfaces were demineralized with 24% EDTA, 0.1 and 1.0 μg/μL BMP-2 solution (15 μL) was applied, and the groups were labeled as low-dose BMP (BL) and high-dose BMP (BH), respectively. In the control roots, phosphate-buffered saline was applied to the root surface. Specimens were histologically analyzed 16 weeks after surgery.Periodontal wound healing was stimulated by conditioning with BMP-2. Formation of alveolar bone and cementum-like tissue was observed; however, in BH group, ankylosis and root resorption were accelerated in the defect area, and there was little evidence of periodontal ligament formation between alveolar bone and root surface.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	日本再生歯科医学会(利用は著作権の範囲内に限られます)
PISSN	1348-9623
EISSN	1880-0823
NCID	AA1195240X
関連情報	NAID 130004456618
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.11223/jarde.8.173