Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet

INOUE, Kana; MIYAJI, Hirofumi; SUGAYA, Tsutomu; KAWANAMI, Masamitsu

Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet

INOUE, Kana; MIYAJI, Hirofumi; SUGAYA, Tsutomu et al.

Journal of Oral Tissue Engineering, 2010, 8(1), 19-29

Permalink : https://hdl.handle.net/2115/59875

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/59875
タイトル	Ectopic Bone Induction by BMP-loaded Collagen Scaffold and Bone Marrow Stromal Cell Sheet
著者	INOUE, Kana ; MIYAJI, Hirofumi ; SUGAYA, Tsutomu ; KAWANAMI, Masamitsu
著者名 INOUE, Kana 著者別名 INOUE, Kana
e-Rad_Researcher 50372256 著者名 MIYAJI, Hirofumi 著者別名 MIYAJI, Hirofumi
e-Rad_Researcher 10211301 著者名 SUGAYA, Tsutomu 著者別名 SUGAYA, Tsutomu
e-Rad_Researcher 10133761 著者名 KAWANAMI, Masamitsu 著者別名 KAWANAMI, Masamitsu
言語	英語
キーワード	bone tissue engineering
	bone marrow stromal cell
	BMP-2
	cell sheet
	collagen sponge scaffold
発行日	2010-09-30
出版者	Japanese Association of Regenerative Dentistry
出版者	日本再生歯科医学会
収録物名	Journal of Oral Tissue Engineering
巻(号)	8(1)
ページ	19-29
抄録	We combined the use of bone morphogenetic protein-2(BMP-2)-loaded collagen scaffold and cultured bone marrow stromal cell (BMSC) sheet in order for developing new bone tissue engineering.Rat BMSC sheets were generated in the presence of dexamethasone, β-glycerophosphate and ascorbic acid. Four types of the grafts were implanted in the intermuscular region of rat femurs: control group, collagen sponge; cell group, BMSC sheet in collagen sponge; BMP group, BMP-2-loaded collagen sponge; and BMP-cell group, BMSC sheet in BMP-2-loaded collagen sponge. Four weeks after surgery, histological and histomorphometric analysis were performed.The BMP-cell group demonstrated abundant new bone formation compared to all the other groups (p<0.05) and marked resorption of the implanted collagen when compared to the control and cell groups (p<0.05).The combination of BMP-2-loaded collagen sponge and BMSC sheet appeared to successfully promote an osteoinduction.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	日本再生歯科医学会(利用は著作権の範囲内に限られます)
PISSN	1348-9623
EISSN	1880-0823
NCID	AA1195240X
関連情報	NAID 130004941161
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.11223/jarde.8.19