A Comparison of the Effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters : A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2)

Nomoto, Hiroshi; Miyoshi, Hideaki; Furumoto, Tomoo; Oba, Koji; Tsutsui, Hiroyuki; Miyoshi, Arina; Kondo, Takuma; Tsuchida, Kenichi; Atsumi, Tatsuya; Manda, Naoki; Kurihara, Yoshio; Aoki, Shin; SAIS Study Group

A Comparison of the Effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters : A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2)

Nomoto, Hiroshi; Miyoshi, Hideaki; Furumoto, Tomoo et al.

PLoS ONE, 2015, 10(8), e0135854

Permalink : https://hdl.handle.net/2115/59900

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アクセス権	open access
URI	https://hdl.handle.net/2115/59900
タイトル	A Comparison of the Effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters : A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2 (SAIS2)
著者	Nomoto, Hiroshi ; Miyoshi, Hideaki ; Furumoto, Tomoo ; Oba, Koji ; Tsutsui, Hiroyuki ; Miyoshi, Arina ; Kondo, Takuma ; Tsuchida, Kenichi ; Atsumi, Tatsuya ; Manda, Naoki ; Kurihara, Yoshio ; Aoki, Shin ; SAIS Study Group
著者名 Nomoto, Hiroshi
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
e-Rad_Researcher 10399925 著者名 Furumoto, Tomoo
e-Rad_Researcher 30422926 著者名 Oba, Koji
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
著者名 Miyoshi, Arina
著者名 Kondo, Takuma
著者名 Tsuchida, Kenichi
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
著者名 Manda, Naoki
著者名 Kurihara, Yoshio
著者名 Aoki, Shin
著者名 SAIS Study Group
言語	英語
発行日	2015-08-19
出版者	PLOS
収録物名	PLoS ONE
巻(号)	10(8)
ページ	e0135854
抄録	Objectives GLP-1 improves hyperglycemia, and it has been reported to have favorable effects on atherosclerosis. However, it has not been fully elucidated whether GLP-1 is able to improve endothelial function in patients with type 2 diabetes. Therefore, we investigated the efficacy of the GLP-1 analogue, liraglutide on endothelial function and glycemic metabolism compared with insulin glargine therapy. Materials and Methods In this multicenter, prospective randomized parallel-group comparison study, 31 diabetic outpatients (aged 60.3 +/- 10.3 years with HbA1c levels of 8.6 +/- 0.8%) with current metformin and/or sulfonylurea treatment were enrolled and randomly assigned to receive liraglutide or glargine therapy once daily for 14 weeks. Flow mediated dilation (FMD), a comprehensive panel of hemodynamic parameters (Task Force Monitor), and serum metabolic markers were assessed before and after the treatment period. Results A greater reduction (worsening) in % FMD was observed in the glargine group, although this change was not statistically different from the liraglutide group (liraglutide; 5.7 to 5.4%, glargine 6.7 to 5.7%). The augmentation index, C-peptide index, derivatives of reactive oxygen metabolites and BMI were significantly improved in the liraglutide group. Central systolic blood pressure and NT-proBNP also tended to be improved in the liraglutide-treated group, while improvements in HbA1c levels were similar between groups. Cardiac index, blood pressure and most other metabolic parameters were not different. Conclusions Regardless of glycemic improvement, early liraglutide therapy did not affect endothelial function but may provide favorable effects on beta-cell function and cardioprotection in type 2 diabetics without advanced atherosclerosis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0135854