Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use

Arsiningtyas, Ines Septi; Gunawan-Puteri, Maria D. P. T.; Kato, Eisuke; Kawabata, Jun

Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use

Arsiningtyas, Ines Septi; Gunawan-Puteri, Maria D. P. T.; Kato, Eisuke et al.

Natural Product Research, 2015, 28(17), 1350-1353

Permalink : https://hdl.handle.net/2115/60048

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アクセス権	open access
URI	https://hdl.handle.net/2115/60048
タイトル	Identification of alpha-glucosidase inhibitors from the leaves of Pluchea indica (L.) Less., a traditional Indonesian herb: promotion of natural product use
著者	Arsiningtyas, Ines Septi ; Gunawan-Puteri, Maria D. P. T. ; Kato, Eisuke ; Kawabata, Jun
著者名 Arsiningtyas, Ines Septi
著者名 Gunawan-Puteri, Maria D. P. T.
e-Rad_Researcher 40466446 著者名 Kato, Eisuke
e-Rad_Researcher 60142197 著者名 Kawabata, Jun
言語	英語
キーワード	Indonesian herb
	intestinal maltase inhibitor
	diabetes mellitus
	Pluchea indica
	caffeoylquinic acid derivatives
発行日	2015-10-15
出版者	Taylor & Francis
収録物名	Natural Product Research
巻(号)	28(17)
ページ	1350-1353
抄録	A promising approach for treating diabetes mellitus (DM) is to decrease postprandial hyperglycaemia by suppressing carbohydrate digestion using a-glucosidase inhibitors. Pluchea indica leaf extracts possess inhibitory activity against intestinal maltase. Enzyme assay-guided fractionation by chromatography yielded five active caffeoylquinic acid derivatives (1-5). Their structures were elucidated by mass spectrometry and NMR analysis and completed by comparison with reference data. 3,5-Di-O-caffeoylquinic acid (1), 4,5-di-O-caffeoylquinic acid methyl ester (2), 3,4,5-tri-O-caffeoylquinic acid methyl ester (3), 3,4,5-tri-O-caffeoylquinic acid (4) and 1,3,4,5-tetra-O-caffeoylquinic acid (5) were isolated. Comparison of the activities of each isolate suggested that both methyl esterification of quinic acid and the number of caffeate groups in the molecule were important for the inhibitory activity. This study provides basic information for further examination of the suitability of P. indica as a functional food and medicinal supplement for the treatment and prevention of diabetes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/DOI:10.1080/14786419.2014.904306.
PISSN	1478-6419
関連情報	PMID 24697406
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/14786419.2014.904306